La scialoendoscopia interventistica per le scialoadeniti radioiodio-indotte: Quo vadis?

Translated title of the contribution: Interventional sialendoscopy for radioiodine-induced sialadenitis: Quo vadis?

Research output: Contribution to journalArticle

Abstract

Salivary gland toxicity is a common adverse effect of radioactive iodine (131I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the131I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatments. The objective of the current review was to assess the impact of this procedure on outcomes in patients suffering from radioiodine sialadenitis. Overall, eight studies were included and 122 patients underwent 264 sialendoscopic procedures. Duct stenosis and mucous plugs were observed in 85.7% of endoscopic findings, supporting the role of ductal obstruction in the pathophysiology of radioiodine sialadenitis. In total, 89.3% of patients experienced complete or partial resolution of sialadenitis recurrences without any major adverse events, and parotidectomy was advocated in only 1 case. However, outcomes mainly concerned subjective reports and only two clinical experiences evaluated objective measurement with dissimilar results. Limited to few studies, xerostomia and obstructive symptoms responded differently after sialendoscopy. The optimal timing of salivary gland videoendoscopy needs to be further analysed in order to define the best management of radioiodine-induced obstructive sialadenitis.

Original languageItalian
Pages (from-to)155-159
Number of pages5
JournalActa Otorhinolaryngologica Italica
Volume37
Issue number2
DOIs
Publication statusPublished - 2017

Fingerprint

Sialadenitis
Salivary Glands
Xerostomia
Thyroid Neoplasms
Iodine
Pathologic Constriction
Therapeutics
Recurrence
Population

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{830ab3c1d13a4de0aa119b8582be917d,
title = "La scialoendoscopia interventistica per le scialoadeniti radioiodio-indotte: Quo vadis?",
abstract = "Salivary gland toxicity is a common adverse effect of radioactive iodine (131I) for the treatment of thyroid cancers with a prevalence ranging from 2{\%} to 67{\%} of the131I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatments. The objective of the current review was to assess the impact of this procedure on outcomes in patients suffering from radioiodine sialadenitis. Overall, eight studies were included and 122 patients underwent 264 sialendoscopic procedures. Duct stenosis and mucous plugs were observed in 85.7{\%} of endoscopic findings, supporting the role of ductal obstruction in the pathophysiology of radioiodine sialadenitis. In total, 89.3{\%} of patients experienced complete or partial resolution of sialadenitis recurrences without any major adverse events, and parotidectomy was advocated in only 1 case. However, outcomes mainly concerned subjective reports and only two clinical experiences evaluated objective measurement with dissimilar results. Limited to few studies, xerostomia and obstructive symptoms responded differently after sialendoscopy. The optimal timing of salivary gland videoendoscopy needs to be further analysed in order to define the best management of radioiodine-induced obstructive sialadenitis.",
keywords = "Endoscopy, Radioiodine, Salivary glands, Sialadenitis, Sialendoscopy",
author = "Pietro Canzi and S. Cacciola and P. Capaccio and F. Pagella and A. Occhini and L. Pignataro and M. Benazzo",
year = "2017",
doi = "10.14639/0392-100X-1606",
language = "Italian",
volume = "37",
pages = "155--159",
journal = "Acta Otorhinolaryngologica Italica",
issn = "0392-100X",
publisher = "Pacini Editore s.r.l.",
number = "2",

}

TY - JOUR

T1 - La scialoendoscopia interventistica per le scialoadeniti radioiodio-indotte

T2 - Quo vadis?

AU - Canzi, Pietro

AU - Cacciola, S.

AU - Capaccio, P.

AU - Pagella, F.

AU - Occhini, A.

AU - Pignataro, L.

AU - Benazzo, M.

PY - 2017

Y1 - 2017

N2 - Salivary gland toxicity is a common adverse effect of radioactive iodine (131I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the131I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatments. The objective of the current review was to assess the impact of this procedure on outcomes in patients suffering from radioiodine sialadenitis. Overall, eight studies were included and 122 patients underwent 264 sialendoscopic procedures. Duct stenosis and mucous plugs were observed in 85.7% of endoscopic findings, supporting the role of ductal obstruction in the pathophysiology of radioiodine sialadenitis. In total, 89.3% of patients experienced complete or partial resolution of sialadenitis recurrences without any major adverse events, and parotidectomy was advocated in only 1 case. However, outcomes mainly concerned subjective reports and only two clinical experiences evaluated objective measurement with dissimilar results. Limited to few studies, xerostomia and obstructive symptoms responded differently after sialendoscopy. The optimal timing of salivary gland videoendoscopy needs to be further analysed in order to define the best management of radioiodine-induced obstructive sialadenitis.

AB - Salivary gland toxicity is a common adverse effect of radioactive iodine (131I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the131I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatments. The objective of the current review was to assess the impact of this procedure on outcomes in patients suffering from radioiodine sialadenitis. Overall, eight studies were included and 122 patients underwent 264 sialendoscopic procedures. Duct stenosis and mucous plugs were observed in 85.7% of endoscopic findings, supporting the role of ductal obstruction in the pathophysiology of radioiodine sialadenitis. In total, 89.3% of patients experienced complete or partial resolution of sialadenitis recurrences without any major adverse events, and parotidectomy was advocated in only 1 case. However, outcomes mainly concerned subjective reports and only two clinical experiences evaluated objective measurement with dissimilar results. Limited to few studies, xerostomia and obstructive symptoms responded differently after sialendoscopy. The optimal timing of salivary gland videoendoscopy needs to be further analysed in order to define the best management of radioiodine-induced obstructive sialadenitis.

KW - Endoscopy

KW - Radioiodine

KW - Salivary glands

KW - Sialadenitis

KW - Sialendoscopy

UR - http://www.scopus.com/inward/record.url?scp=85019233100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019233100&partnerID=8YFLogxK

U2 - 10.14639/0392-100X-1606

DO - 10.14639/0392-100X-1606

M3 - Articolo

AN - SCOPUS:85019233100

VL - 37

SP - 155

EP - 159

JO - Acta Otorhinolaryngologica Italica

JF - Acta Otorhinolaryngologica Italica

SN - 0392-100X

IS - 2

ER -