Intestinal amyloidosis: Two cases with different patterns of clinical and imaging presentation

Pier Paolo Mainenti, Sabrina Segreto, Marcello Mancini, Antonio Rispo, Immacolata Cozzolino, Stefania Masone, Ciro Roberto Rinaldi, Gerardo Nardone, Marco Salvatore

Research output: Contribution to journalArticlepeer-review


The involvement of the small bowel in systemic forms of amyloidosis may be diffuse or very rarely focal. Some cases of focal amyloidomas of the duodenum and jejunum without extraintestinal manifestations have been reported. The focal amyloidomas consisted of extensive amyloid infiltration of the entire intestinal wall thickness. Radiological barium studies, ultrasound and computed tomography (CT) patterns of diffuse small bowel amyloidosis have been described: the signs are non-specific and may include small-bowel dilatation, symmetric bowel wall thickening, mesenteric infiltration, and mesenteric adenopathy. No data are available about the positron emission tomography (PET)/CT and magnetic resonance imaging (MRI) patterns of intestinal amyloidosis. We report two cases of small bowel amyloidosis: the former characterized by focal deposition of amyloid proteins exclusively within blood vessel walls of the terminal ileum, the latter characterized by diffuse intestinal involvement observed on MRI and PET/CT studies.

Original languageEnglish
Pages (from-to)2566-2570
Number of pages5
JournalWorld Journal of Gastroenterology
Issue number20
Publication statusPublished - May 28 2010


  • Amyloidosis
  • Computed tomography
  • Magnetic resonance imaging
  • Positron emission tomography/computed tomography
  • Small bowel

ASJC Scopus subject areas

  • Gastroenterology


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