L'assorbimento intestinale del colesterolo: Un bersaglio farmacologico per il controllo dei livelli di colesterolo plasmatici

Translated title of the contribution: Intestinal cholesterol absorption: A pharmacological target to control plasma cholesterol levels

Alberico L. Catapano, Luca Catapano, Renato Fellin

Research output: Contribution to journalArticle

Abstract

A number of clinical studies clearly demonstrate the efficacy of hypocholesterolemic treatment in reducing incident cardiovascular events. The benefit appears to be proportional to the reduction of LDL cholesterol. Recent guidelines suggest an even more stringent target of 70 mg/dl for LDL cholesterol in high-risk subjects. Statins represent a very effective treatment of hypercholesterolemia, and the co-administration of drugs with complementary mechanisms of action, may represent an additional pharmacological tool in clinical practice to achieve the suggested targets for LDL lowering. In this short review we address the most recent discoveries in the physiological pathways of cholesterol absorption and identify the concept of dual inhibition as a therapeutic paradigm that may help in reaching the LDL cholesterol targets in clinical practice.

Original languageItalian
Pages (from-to)779-784
Number of pages6
JournalItalian Heart Journal Supplement
Volume5
Issue number10
Publication statusPublished - 2004

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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