Intestinal Dendritic Cells

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Dendritic cells (DCs) are specialized antigen-presenting cells that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs that are highly specialized in function. Mucosal DCs display a unique response to toll-like receptor ligands, are capable of driving immunoglobulin isotype switching to IgA, can imprint gut-homing receptors on T and B cells, and drive either T regulatory or Th17 cells depending on the analyzed subtype. These functions are partly cell autonomous and partly conferred by the local microenvironment. In this review, we will summarize the different DC subtypes present in the intestine and in the gut-associated lymphoid tissue (GALT), the unique characteristics of these subtypes, and how the local microenvironment can shape DC function.

Original languageEnglish
Pages (from-to)109-138
Number of pages30
JournalAdvances in Immunology
Volume107
Issue numberC
DOIs
Publication statusPublished - 2010

Fingerprint

Dendritic Cells
Immunoglobulin Class Switching
Th17 Cells
Immunoglobulin Isotypes
Toll-Like Receptors
Adaptive Immunity
Lymphoid Tissue
Antigen-Presenting Cells
Intestinal Mucosa
Innate Immunity
Immunoglobulin A
Intestines
B-Lymphocytes
Ligands
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Intestinal Dendritic Cells. / Rescigno, Maria.

In: Advances in Immunology, Vol. 107, No. C, 2010, p. 109-138.

Research output: Contribution to journalArticle

Rescigno, Maria. / Intestinal Dendritic Cells. In: Advances in Immunology. 2010 ; Vol. 107, No. C. pp. 109-138.
@article{96d35cdc83ab4a759355cfb7129192da,
title = "Intestinal Dendritic Cells",
abstract = "Dendritic cells (DCs) are specialized antigen-presenting cells that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs that are highly specialized in function. Mucosal DCs display a unique response to toll-like receptor ligands, are capable of driving immunoglobulin isotype switching to IgA, can imprint gut-homing receptors on T and B cells, and drive either T regulatory or Th17 cells depending on the analyzed subtype. These functions are partly cell autonomous and partly conferred by the local microenvironment. In this review, we will summarize the different DC subtypes present in the intestine and in the gut-associated lymphoid tissue (GALT), the unique characteristics of these subtypes, and how the local microenvironment can shape DC function.",
author = "Maria Rescigno",
year = "2010",
doi = "10.1016/B978-0-12-381300-8.00004-6",
language = "English",
volume = "107",
pages = "109--138",
journal = "Advances in Immunology",
issn = "0065-2776",
publisher = "Academic Press Inc.",
number = "C",

}

TY - JOUR

T1 - Intestinal Dendritic Cells

AU - Rescigno, Maria

PY - 2010

Y1 - 2010

N2 - Dendritic cells (DCs) are specialized antigen-presenting cells that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs that are highly specialized in function. Mucosal DCs display a unique response to toll-like receptor ligands, are capable of driving immunoglobulin isotype switching to IgA, can imprint gut-homing receptors on T and B cells, and drive either T regulatory or Th17 cells depending on the analyzed subtype. These functions are partly cell autonomous and partly conferred by the local microenvironment. In this review, we will summarize the different DC subtypes present in the intestine and in the gut-associated lymphoid tissue (GALT), the unique characteristics of these subtypes, and how the local microenvironment can shape DC function.

AB - Dendritic cells (DCs) are specialized antigen-presenting cells that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs that are highly specialized in function. Mucosal DCs display a unique response to toll-like receptor ligands, are capable of driving immunoglobulin isotype switching to IgA, can imprint gut-homing receptors on T and B cells, and drive either T regulatory or Th17 cells depending on the analyzed subtype. These functions are partly cell autonomous and partly conferred by the local microenvironment. In this review, we will summarize the different DC subtypes present in the intestine and in the gut-associated lymphoid tissue (GALT), the unique characteristics of these subtypes, and how the local microenvironment can shape DC function.

UR - http://www.scopus.com/inward/record.url?scp=77958475318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958475318&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-381300-8.00004-6

DO - 10.1016/B978-0-12-381300-8.00004-6

M3 - Article

C2 - 21034972

AN - SCOPUS:77958475318

VL - 107

SP - 109

EP - 138

JO - Advances in Immunology

JF - Advances in Immunology

SN - 0065-2776

IS - C

ER -