The serum anti-transglutaminase antibodies are the immunological markers for coeliac disease diagnosis. These autoantibodies are synthesized by B-lymphocytes at the intestinal level and their presence in the form of intestinal deposits is a constant feature in the different clinical entities in which coeliac disease is classified: classical, silent, and potential. These intestinal autoantibodies are the first gluten dependent inflammatory markers and they appear before both the intestinal damage and the serum anti-transglutaminase antibodies. The anti-transglutaminase deposits should be looked for to confirm or exclude the diagnosis of coeliac disease when the clinical and immunological features are incomplete or in asymptomatic at risk patients.
|Number of pages||3|
|Journal||Medico e Bambino|
|Publication status||Published - Mar 1 2016|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health