I depositi intestinali degli anticorpi anti-transglutaminasi: Il marcatore più sensibile per la diagnosi di celiachia nei casi difficili

Translated title of the contribution: Intestinal deposits of anti-transglutaminase antibodies

Luigina De Leo, Ilma Korponai-Szabo, Markku Mäki, Grazia Di Leo, Stefano Martelossi, Vincenzo Villanacci, Tarcisio Not, Alessandro Ventura

Research output: Contribution to journalArticle

Abstract

The serum anti-transglutaminase antibodies are the immunological markers for coeliac disease diagnosis. These autoantibodies are synthesized by B-lymphocytes at the intestinal level and their presence in the form of intestinal deposits is a constant feature in the different clinical entities in which coeliac disease is classified: classical, silent, and potential. These intestinal autoantibodies are the first gluten dependent inflammatory markers and they appear before both the intestinal damage and the serum anti-transglutaminase antibodies. The anti-transglutaminase deposits should be looked for to confirm or exclude the diagnosis of coeliac disease when the clinical and immunological features are incomplete or in asymptomatic at risk patients.

Original languageItalian
Pages (from-to)174-176
Number of pages3
JournalMedico e Bambino
Volume35
Issue number3
Publication statusPublished - Mar 1 2016

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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