Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

Monica Rimoldi, Marcello Chieppa, Valentina Salucci, Francesca Avogadri, Angelica Sonzogni, Gianluca M. Sampietro, Angelo Nespoli, Giuseppe Viale, Paola Allavena, Maria Rescigno

Research output: Contribution to journalArticlepeer-review

Abstract

The control of damaging inflammation by the mucosal immune system in response to commensal and harmful ingested bacteria is unknown. Here we show epithelial cells conditioned mucosal dendritic cells through the constitutive release of thymic stromal lymphopoietin and other mediators, resulting in the induction of 'noninflammatory' dendritic cells. Epithelial cell-conditioned dendritic cells released interleukins 10 and 6 but not interleukin 12, and they promoted the polarization of T cells toward a 'classical' noninflammatory T helper type 2 response, even after exposure to a T helper type 1-inducing pathogen. This control of immune responses seemed to be lost in patients with Crohn disease. Thus, the intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalNature Immunology
Volume6
Issue number5
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Immunology

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