Intestinal macrophages at the crossroad between diet, inflammation, and cancer: International Journal of Molecular Sciences

G. Caprara; P. Allavena; M. Erreni

doi:10.3390/ijms21144825

Intestinal macrophages at the crossroad between diet, inflammation, and cancer: International Journal of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Intestinal macrophages are key players in the regulation of the oral tolerance, controlling gut homeostasis by discriminating innocuous antigens from harmful pathogens. Diet exerts a significant impact on human health, influencing the composition of gut microbiota and the developing of several non-communicable diseases, including cancer. Nutrients and microbiota are able to modify the profile of intestinal macrophages, shaping their key function in the maintenance of the gut homeostasis. Intestinal disease often occurs as a breakdown of this balance: defects in monocyte–macrophage differentiation, wrong dietary habits, alteration of microbiota composition, and impairment in the resolution of inflammation may contribute to the development of intestinal chronic inflammation and colorectal cancer. Accordingly, dietary interventions and macrophage-targeted therapies are emerging as innovative tools for the treatment of several intestinal pathologies. In this review, we will describe the delicate balance between diet, microbiota and intestinal macrophages in homeostasis and how the perturbation of this equilibrium may lead to the occurrence of inflammatory conditions in the gut. The understanding of the molecular pathways and dietary factors regulating the activity of intestinal macrophages might result in the identification of innovative targets for the treatments of intestinal pathologies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Original language	English
Pages (from-to)	1-31
Number of pages	31
Journal	Int. J. Mol. Sci.
Volume	21
Issue number	14
DOIs	https://doi.org/10.3390/ijms21144825
Publication status	Published - 2020

Keywords

Colorectal cancer
Diet
Gut
Inflammation
Intestine
Macrophage
Microbiota
Tumor-associated macrophage
alphaVbeta5 integrin
B7 antigen
CD40 antigen
chemokine receptor CCR2
chemokine receptor CX3CR1
fractalkine
interleukin 10
interleukin 10 receptor
interleukin 6
interleukin 8
monocyte chemotactic protein 1
omega 3 fatty acid
retinol
saturated fatty acid
short chain fatty acid
toll like receptor 2
trace element
transcription factor RUNX3
transforming growth factor beta
vitamin D
cell differentiation
colorectal cancer
diet therapy
dietary fiber
down regulation
environmental factor
gene expression
human
immune response
inflammatory bowel disease
intestine cell
intestine flora
intestine infection
macrophage
missense mutation
nonhuman
processed meat
protein expression
protein localization
red meat
Review
tissue repair
tumor associated leukocyte
upregulation
Western diet

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10.3390/ijms21144825

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@article{95fbd777ac1946a488c341b8ccf5b0c5,

title = "Intestinal macrophages at the crossroad between diet, inflammation, and cancer: International Journal of Molecular Sciences",

abstract = "Intestinal macrophages are key players in the regulation of the oral tolerance, controlling gut homeostasis by discriminating innocuous antigens from harmful pathogens. Diet exerts a significant impact on human health, influencing the composition of gut microbiota and the developing of several non-communicable diseases, including cancer. Nutrients and microbiota are able to modify the profile of intestinal macrophages, shaping their key function in the maintenance of the gut homeostasis. Intestinal disease often occurs as a breakdown of this balance: defects in monocyte–macrophage differentiation, wrong dietary habits, alteration of microbiota composition, and impairment in the resolution of inflammation may contribute to the development of intestinal chronic inflammation and colorectal cancer. Accordingly, dietary interventions and macrophage-targeted therapies are emerging as innovative tools for the treatment of several intestinal pathologies. In this review, we will describe the delicate balance between diet, microbiota and intestinal macrophages in homeostasis and how the perturbation of this equilibrium may lead to the occurrence of inflammatory conditions in the gut. The understanding of the molecular pathways and dietary factors regulating the activity of intestinal macrophages might result in the identification of innovative targets for the treatments of intestinal pathologies. {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

keywords = "Colorectal cancer, Diet, Gut, Inflammation, Intestine, Macrophage, Microbiota, Tumor-associated macrophage, alphaVbeta5 integrin, B7 antigen, CD40 antigen, chemokine receptor CCR2, chemokine receptor CX3CR1, fractalkine, interleukin 10, interleukin 10 receptor, interleukin 6, interleukin 8, monocyte chemotactic protein 1, omega 3 fatty acid, retinol, saturated fatty acid, short chain fatty acid, toll like receptor 2, trace element, transcription factor RUNX3, transforming growth factor beta, vitamin D, cell differentiation, colorectal cancer, diet therapy, dietary fiber, down regulation, environmental factor, gene expression, human, immune response, inflammatory bowel disease, intestine cell, intestine flora, intestine infection, macrophage, missense mutation, nonhuman, processed meat, protein expression, protein localization, red meat, Review, tissue repair, tumor associated leukocyte, upregulation, Western diet",

author = "G. Caprara and P. Allavena and M. Erreni",

note = "Cited By :5 Export Date: 2 March 2021 Correspondence Address: Erreni, M.; Unit of Advanced Optical Microscopy, via Manzoni 56, Italy; email: marco.erreni@humanitasresearch.it Chemicals/CAS: fractalkine, 199619-66-4; interleukin 8, 114308-91-7; retinol, 68-26-8, 82445-97-4; toll like receptor 2, 203811-81-8 Funding details: Associazione Italiana per la Ricerca sul Cancro, AIRC, 21147 Funding text 1: Funding: This research was funded by AIRC 5 × 1000 grant no. 21147 to Alberto Mantovani. References: Bain, C.C., Mowat, A.M., Macrophages in intestinal homeostasis and inflammation (2014) Immunol. Rev, 260, pp. 102-117. , [CrossRef]; van Furth, R., Cohn, Z.A., The origin and kinetics of mononuclear phagocytes (1968) J. Exp. 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year = "2020",

doi = "10.3390/ijms21144825",

language = "English",

volume = "21",

pages = "1--31",

journal = "Int. J. Mol. Sci.",

issn = "1661-6596",

publisher = "MDPI AG",

number = "14",

}

TY - JOUR

T1 - Intestinal macrophages at the crossroad between diet, inflammation, and cancer

T2 - International Journal of Molecular Sciences

AU - Caprara, G.

AU - Allavena, P.

AU - Erreni, M.

N1 - Cited By :5 Export Date: 2 March 2021 Correspondence Address: Erreni, M.; Unit of Advanced Optical Microscopy, via Manzoni 56, Italy; email: marco.erreni@humanitasresearch.it Chemicals/CAS: fractalkine, 199619-66-4; interleukin 8, 114308-91-7; retinol, 68-26-8, 82445-97-4; toll like receptor 2, 203811-81-8 Funding details: Associazione Italiana per la Ricerca sul Cancro, AIRC, 21147 Funding text 1: Funding: This research was funded by AIRC 5 × 1000 grant no. 21147 to Alberto Mantovani. References: Bain, C.C., Mowat, A.M., Macrophages in intestinal homeostasis and inflammation (2014) Immunol. Rev, 260, pp. 102-117. , [CrossRef]; van Furth, R., Cohn, Z.A., The origin and kinetics of mononuclear phagocytes (1968) J. Exp. 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PY - 2020

Y1 - 2020

N2 - Intestinal macrophages are key players in the regulation of the oral tolerance, controlling gut homeostasis by discriminating innocuous antigens from harmful pathogens. Diet exerts a significant impact on human health, influencing the composition of gut microbiota and the developing of several non-communicable diseases, including cancer. Nutrients and microbiota are able to modify the profile of intestinal macrophages, shaping their key function in the maintenance of the gut homeostasis. Intestinal disease often occurs as a breakdown of this balance: defects in monocyte–macrophage differentiation, wrong dietary habits, alteration of microbiota composition, and impairment in the resolution of inflammation may contribute to the development of intestinal chronic inflammation and colorectal cancer. Accordingly, dietary interventions and macrophage-targeted therapies are emerging as innovative tools for the treatment of several intestinal pathologies. In this review, we will describe the delicate balance between diet, microbiota and intestinal macrophages in homeostasis and how the perturbation of this equilibrium may lead to the occurrence of inflammatory conditions in the gut. The understanding of the molecular pathways and dietary factors regulating the activity of intestinal macrophages might result in the identification of innovative targets for the treatments of intestinal pathologies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

AB - Intestinal macrophages are key players in the regulation of the oral tolerance, controlling gut homeostasis by discriminating innocuous antigens from harmful pathogens. Diet exerts a significant impact on human health, influencing the composition of gut microbiota and the developing of several non-communicable diseases, including cancer. Nutrients and microbiota are able to modify the profile of intestinal macrophages, shaping their key function in the maintenance of the gut homeostasis. Intestinal disease often occurs as a breakdown of this balance: defects in monocyte–macrophage differentiation, wrong dietary habits, alteration of microbiota composition, and impairment in the resolution of inflammation may contribute to the development of intestinal chronic inflammation and colorectal cancer. Accordingly, dietary interventions and macrophage-targeted therapies are emerging as innovative tools for the treatment of several intestinal pathologies. In this review, we will describe the delicate balance between diet, microbiota and intestinal macrophages in homeostasis and how the perturbation of this equilibrium may lead to the occurrence of inflammatory conditions in the gut. The understanding of the molecular pathways and dietary factors regulating the activity of intestinal macrophages might result in the identification of innovative targets for the treatments of intestinal pathologies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

KW - Colorectal cancer

KW - Diet

KW - Gut

KW - Inflammation

KW - Intestine

KW - Macrophage

KW - Microbiota

KW - Tumor-associated macrophage

KW - alphaVbeta5 integrin

KW - B7 antigen

KW - CD40 antigen

KW - chemokine receptor CCR2

KW - chemokine receptor CX3CR1

KW - fractalkine

KW - interleukin 10

KW - interleukin 10 receptor

KW - interleukin 6

KW - interleukin 8

KW - monocyte chemotactic protein 1

KW - omega 3 fatty acid

KW - retinol

KW - saturated fatty acid

KW - short chain fatty acid

KW - toll like receptor 2

KW - trace element

KW - transcription factor RUNX3

KW - transforming growth factor beta

KW - vitamin D

KW - cell differentiation

KW - colorectal cancer

KW - diet therapy

KW - dietary fiber

KW - down regulation

KW - environmental factor

KW - gene expression

KW - human

KW - immune response

KW - inflammatory bowel disease

KW - intestine cell

KW - intestine flora

KW - intestine infection

KW - macrophage

KW - missense mutation

KW - nonhuman

KW - processed meat

KW - protein expression

KW - protein localization

KW - red meat

KW - Review

KW - tissue repair

KW - tumor associated leukocyte

KW - upregulation

KW - Western diet

U2 - 10.3390/ijms21144825

DO - 10.3390/ijms21144825

M3 - Article

VL - 21

SP - 1

EP - 31

JO - Int. J. Mol. Sci.

JF - Int. J. Mol. Sci.

SN - 1661-6596

IS - 14

ER -

Intestinal macrophages at the crossroad between diet, inflammation, and cancer: International Journal of Molecular Sciences

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