Intestinal microbiota and its effects on the immune system

Research output: Contribution to journalArticle

Abstract

Summary: The microbiota colonizes every surface exposed to the external world and in the gut, it plays important roles in physiological functions such as the maturation of the immune system, the degradation of complex food macromolecules and also behaviour. As such, the immune system has developed tools to cohabit with the microbiota, but also to keep it under control. When this control is lost, dysbiosis, i.e. deregulation in bacterial communities, can occur and this can lead to inflammatory disorders, including inflammatory bowel disease, obesity, diabetes and autism. For these reasons, the analysis of the microbiota, its interactions with the host and its composition in disease, have been intensively investigated in the last few years. In this review, we summarize the major findings in the interaction of the microbiota with the host immune system.

Original languageEnglish
Pages (from-to)1004-1013
Number of pages10
JournalCellular Microbiology
Volume16
Issue number7
DOIs
Publication statusPublished - 2014

    Fingerprint

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology
  • Medicine(all)

Cite this