Abstract
We studied 14 patients with irritable bowel syndrome for the presence of increased intestinal permeability to food antigens and their responses to diet with and without disodium cromoglycate. After a standardized oral challenge with cow milk, serum β-lactoglobulin was increased above control values in three patients. This finding did not correlate with response to hypoallergenic diet or treatment with disodium cromoglycate for 3 weeks. However over 50% of patients improved after diet with and without DSCG (2/5 on diet only and 5/7 with disodium cromoglycate of 12 evaluable cases). Since only two patients had elevated serum IgE levels, our results suggest that intolerance rather than hypersensitivity to foods may play a role in this disease. The tests we used to identify immmunologic mechanisms could not predict which patients would do better on the diet and/or the drug.
| Original language | English |
|---|---|
| Pages (from-to) | 377-380 |
| Number of pages | 4 |
| Journal | Annals of Allergy |
| Volume | 64 |
| Issue number | 4 |
| Publication status | Published - 1990 |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration. / Paganelli, R.; Fagiolo, U.; Cancian, M.; Sturniolo, G. C.; Scala, E.; D'Offizi, G. P.
In: Annals of Allergy, Vol. 64, No. 4, 1990, p. 377-380.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration
AU - Paganelli, R.
AU - Fagiolo, U.
AU - Cancian, M.
AU - Sturniolo, G. C.
AU - Scala, E.
AU - D'Offizi, G. P.
PY - 1990
Y1 - 1990
N2 - We studied 14 patients with irritable bowel syndrome for the presence of increased intestinal permeability to food antigens and their responses to diet with and without disodium cromoglycate. After a standardized oral challenge with cow milk, serum β-lactoglobulin was increased above control values in three patients. This finding did not correlate with response to hypoallergenic diet or treatment with disodium cromoglycate for 3 weeks. However over 50% of patients improved after diet with and without DSCG (2/5 on diet only and 5/7 with disodium cromoglycate of 12 evaluable cases). Since only two patients had elevated serum IgE levels, our results suggest that intolerance rather than hypersensitivity to foods may play a role in this disease. The tests we used to identify immmunologic mechanisms could not predict which patients would do better on the diet and/or the drug.
AB - We studied 14 patients with irritable bowel syndrome for the presence of increased intestinal permeability to food antigens and their responses to diet with and without disodium cromoglycate. After a standardized oral challenge with cow milk, serum β-lactoglobulin was increased above control values in three patients. This finding did not correlate with response to hypoallergenic diet or treatment with disodium cromoglycate for 3 weeks. However over 50% of patients improved after diet with and without DSCG (2/5 on diet only and 5/7 with disodium cromoglycate of 12 evaluable cases). Since only two patients had elevated serum IgE levels, our results suggest that intolerance rather than hypersensitivity to foods may play a role in this disease. The tests we used to identify immmunologic mechanisms could not predict which patients would do better on the diet and/or the drug.
UR - http://www.scopus.com/inward/record.url?scp=0025350779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025350779&partnerID=8YFLogxK
M3 - Article
C2 - 2108592
AN - SCOPUS:0025350779
VL - 64
SP - 377
EP - 380
JO - Annals of Allergy
JF - Annals of Allergy
SN - 0003-4738
IS - 4
ER -