Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration

R. Paganelli, U. Fagiolo, M. Cancian, G. C. Sturniolo, E. Scala, G. P. D'Offizi

Research output: Contribution to journalArticle

Abstract

We studied 14 patients with irritable bowel syndrome for the presence of increased intestinal permeability to food antigens and their responses to diet with and without disodium cromoglycate. After a standardized oral challenge with cow milk, serum β-lactoglobulin was increased above control values in three patients. This finding did not correlate with response to hypoallergenic diet or treatment with disodium cromoglycate for 3 weeks. However over 50% of patients improved after diet with and without DSCG (2/5 on diet only and 5/7 with disodium cromoglycate of 12 evaluable cases). Since only two patients had elevated serum IgE levels, our results suggest that intolerance rather than hypersensitivity to foods may play a role in this disease. The tests we used to identify immmunologic mechanisms could not predict which patients would do better on the diet and/or the drug.

Original languageEnglish
Pages (from-to)377-380
Number of pages4
JournalAnnals of Allergy
Volume64
Issue number4
Publication statusPublished - 1990

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Cromolyn Sodium
Irritable Bowel Syndrome
Permeability
Diet
Lactoglobulins
Food Hypersensitivity
Serum
Immunoglobulin E
Milk
Antigens
Food
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration. / Paganelli, R.; Fagiolo, U.; Cancian, M.; Sturniolo, G. C.; Scala, E.; D'Offizi, G. P.

In: Annals of Allergy, Vol. 64, No. 4, 1990, p. 377-380.

Research output: Contribution to journalArticle

Paganelli, R. ; Fagiolo, U. ; Cancian, M. ; Sturniolo, G. C. ; Scala, E. ; D'Offizi, G. P. / Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration. In: Annals of Allergy. 1990 ; Vol. 64, No. 4. pp. 377-380.
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