Abstract
The Carotid Atherosclerosis Italian Ultrasound study (CAIUS), a multicenter, double-blind clinical trial, performed in 305 asymptomatic, moderately hypercholesterolemic patients, clearly demonstrated beneficial effects of pravastatin on the carotid intima-media thickness (IMT) progression. The database of the CAIUS study was examined in order to investigate the presence of a relationship, if any, between the activity of pravastatin on IMT progression rate and its hypocholesterolemic effect. Quantitative B-mode ultrasound imaging was used to quantify the individual mean maximum IMT progression rate in 3 years. In the overall group of patients (placebo and pravastatin) covariance analysis showed that while the variable 'treatment' (0 = placebo, 1 = pravastatin) was significantly related to the reduction of IMT progression (F = 6.6, P = 0.01), the IMT progression did not correlate with the extent of LDL-C lowering (F = 0.00, P = 0.98). To further investigate this issue, the pravastatin treated group was stratified into quartiles of LDL-C reduction. In contrast to what was observed in the placebo group, in which a positive mean IMT progression rate was observed, independent of the extent of LDL-C reduction, no IMT progression was observed in any subgroup treated with pravastatin. No significant difference was found among quartiles and no trend could be identified. In conclusion, the effect of pravastatin treatment on carotid IMT progression rate is beneficial; however the CAIUS study demonstrated that lowering LDL-C by itself, does not explain the variability of beneficial changes in IMT. (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 575-583 |
| Number of pages | 9 |
| Journal | Atherosclerosis |
| Volume | 151 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2000 |
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Keywords
- Carotid atherosclerosis
- IMT progression
- Long-term therapy
- Pravastatin
- Ultrasound
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Intima-media thickness after pravastatin stabilizes also in patients with moderate to no reduction in LDL-cholesterol levels : The carotid atherosclerosis Italian ultrasound study. / Baldassarre, Damiano; Veglia, Fabrizio; Gobbi, Cecilia; Gallus, Giuseppe; Ventura, Alessandro; Crepaldi, Gaetano; Fisicaro, Maurizio; Rimondi, Silvana; Ricci, Giorgio; Mancini, Mario; Bond, M. Gene; Collatina, Stefano; Sirtori, Cesare R.
In: Atherosclerosis, Vol. 151, No. 2, 08.2000, p. 575-583.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intima-media thickness after pravastatin stabilizes also in patients with moderate to no reduction in LDL-cholesterol levels
T2 - The carotid atherosclerosis Italian ultrasound study
AU - Baldassarre, Damiano
AU - Veglia, Fabrizio
AU - Gobbi, Cecilia
AU - Gallus, Giuseppe
AU - Ventura, Alessandro
AU - Crepaldi, Gaetano
AU - Fisicaro, Maurizio
AU - Rimondi, Silvana
AU - Ricci, Giorgio
AU - Mancini, Mario
AU - Bond, M. Gene
AU - Collatina, Stefano
AU - Sirtori, Cesare R.
PY - 2000/8
Y1 - 2000/8
N2 - The Carotid Atherosclerosis Italian Ultrasound study (CAIUS), a multicenter, double-blind clinical trial, performed in 305 asymptomatic, moderately hypercholesterolemic patients, clearly demonstrated beneficial effects of pravastatin on the carotid intima-media thickness (IMT) progression. The database of the CAIUS study was examined in order to investigate the presence of a relationship, if any, between the activity of pravastatin on IMT progression rate and its hypocholesterolemic effect. Quantitative B-mode ultrasound imaging was used to quantify the individual mean maximum IMT progression rate in 3 years. In the overall group of patients (placebo and pravastatin) covariance analysis showed that while the variable 'treatment' (0 = placebo, 1 = pravastatin) was significantly related to the reduction of IMT progression (F = 6.6, P = 0.01), the IMT progression did not correlate with the extent of LDL-C lowering (F = 0.00, P = 0.98). To further investigate this issue, the pravastatin treated group was stratified into quartiles of LDL-C reduction. In contrast to what was observed in the placebo group, in which a positive mean IMT progression rate was observed, independent of the extent of LDL-C reduction, no IMT progression was observed in any subgroup treated with pravastatin. No significant difference was found among quartiles and no trend could be identified. In conclusion, the effect of pravastatin treatment on carotid IMT progression rate is beneficial; however the CAIUS study demonstrated that lowering LDL-C by itself, does not explain the variability of beneficial changes in IMT. (C) 2000 Elsevier Science Ireland Ltd.
AB - The Carotid Atherosclerosis Italian Ultrasound study (CAIUS), a multicenter, double-blind clinical trial, performed in 305 asymptomatic, moderately hypercholesterolemic patients, clearly demonstrated beneficial effects of pravastatin on the carotid intima-media thickness (IMT) progression. The database of the CAIUS study was examined in order to investigate the presence of a relationship, if any, between the activity of pravastatin on IMT progression rate and its hypocholesterolemic effect. Quantitative B-mode ultrasound imaging was used to quantify the individual mean maximum IMT progression rate in 3 years. In the overall group of patients (placebo and pravastatin) covariance analysis showed that while the variable 'treatment' (0 = placebo, 1 = pravastatin) was significantly related to the reduction of IMT progression (F = 6.6, P = 0.01), the IMT progression did not correlate with the extent of LDL-C lowering (F = 0.00, P = 0.98). To further investigate this issue, the pravastatin treated group was stratified into quartiles of LDL-C reduction. In contrast to what was observed in the placebo group, in which a positive mean IMT progression rate was observed, independent of the extent of LDL-C reduction, no IMT progression was observed in any subgroup treated with pravastatin. No significant difference was found among quartiles and no trend could be identified. In conclusion, the effect of pravastatin treatment on carotid IMT progression rate is beneficial; however the CAIUS study demonstrated that lowering LDL-C by itself, does not explain the variability of beneficial changes in IMT. (C) 2000 Elsevier Science Ireland Ltd.
KW - Carotid atherosclerosis
KW - IMT progression
KW - Long-term therapy
KW - Pravastatin
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=0033867026&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033867026&partnerID=8YFLogxK
U2 - 10.1016/S0021-9150(99)00434-7
DO - 10.1016/S0021-9150(99)00434-7
M3 - Article
C2 - 10924737
AN - SCOPUS:0033867026
VL - 151
SP - 575
EP - 583
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -