L'intolleranza ad additivi alimentari: Un update

Translated title of the contribution: Intolerance to food additives: an update

F. Cardinale, F. Mangini, M. Berardi, M. Sterpeta Loffredo, I. Chinellato, A. Dellino, F. Cristofori, F. Di Domenico, M. F. Mastrototaro, A. Cappiello, T. Centoducati, F. Carella, L. Armenio

Research output: Contribution to journalArticle

Abstract

Contrary to common believing, the prevalence of the intolerance to food additives in the general population is rather low. Nowadays many doubts persist with regard both to the pathogenetic mechanisms and to the clinical and diagnostic aspects in this field. Symptoms due to, or exacerbated from, food additives usually involve non-IgE-mediate mechanisms (pseudo-allergic reactions, PAR) and are usually less severe of those induced by food allergy. The most frequent clinical feature of the intolerance to food additives still remains the urticaria-angioedema syndrome, although these substances are really involved only in a minority of patients. Other possible clinical features include anaphylaxis, atopic eczema, behaviour disturbances, asthma and non-allergic rhinitis. The diagnostic approach consists in diary cards, reporting symptoms and food habits, elimination diet and double blinded placebo-controlled oral challenge with suspected additives. However, such procedure still remains poorly standardized and numerous uncertainties persist with regard to optimal conditions for performing and interpret the challenge results. The therapeutic approach consists in the exclusion of foods and products containing the additive involved, and, in patients not compliant to the diet, in treatment with symptomatic drugs.

Original languageItalian
Pages (from-to)1401-1409
Number of pages9
JournalMinerva Pediatrica
Volume60
Issue number6
Publication statusPublished - Dec 2008

Fingerprint

Food Additives
Diet
Angioedema
Food Hypersensitivity
Urticaria
Anaphylaxis
Feeding Behavior
Atopic Dermatitis
Rhinitis
Uncertainty
Hypersensitivity
Asthma
Placebos
Food
Therapeutics
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cardinale, F., Mangini, F., Berardi, M., Sterpeta Loffredo, M., Chinellato, I., Dellino, A., ... Armenio, L. (2008). L'intolleranza ad additivi alimentari: Un update. Minerva Pediatrica, 60(6), 1401-1409.

L'intolleranza ad additivi alimentari : Un update. / Cardinale, F.; Mangini, F.; Berardi, M.; Sterpeta Loffredo, M.; Chinellato, I.; Dellino, A.; Cristofori, F.; Di Domenico, F.; Mastrototaro, M. F.; Cappiello, A.; Centoducati, T.; Carella, F.; Armenio, L.

In: Minerva Pediatrica, Vol. 60, No. 6, 12.2008, p. 1401-1409.

Research output: Contribution to journalArticle

Cardinale, F, Mangini, F, Berardi, M, Sterpeta Loffredo, M, Chinellato, I, Dellino, A, Cristofori, F, Di Domenico, F, Mastrototaro, MF, Cappiello, A, Centoducati, T, Carella, F & Armenio, L 2008, 'L'intolleranza ad additivi alimentari: Un update', Minerva Pediatrica, vol. 60, no. 6, pp. 1401-1409.
Cardinale F, Mangini F, Berardi M, Sterpeta Loffredo M, Chinellato I, Dellino A et al. L'intolleranza ad additivi alimentari: Un update. Minerva Pediatrica. 2008 Dec;60(6):1401-1409.
Cardinale, F. ; Mangini, F. ; Berardi, M. ; Sterpeta Loffredo, M. ; Chinellato, I. ; Dellino, A. ; Cristofori, F. ; Di Domenico, F. ; Mastrototaro, M. F. ; Cappiello, A. ; Centoducati, T. ; Carella, F. ; Armenio, L. / L'intolleranza ad additivi alimentari : Un update. In: Minerva Pediatrica. 2008 ; Vol. 60, No. 6. pp. 1401-1409.
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