Intolerant contact lens wearers exhibit ocular surface impairment despite 3 months wear discontinuation

Giuseppe Giannaccare, William Blalock, Michela Fresina, Aldo Vagge, Piera Versura

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate ocular surface (OS) parameters recovery in intolerant contact lens (CL) wearers after a period of discontinuation. Methods: This is a retrospective analysis of data from 87 intolerant CL wearers who had discontinued their use for an average period of 12 weeks because of associated discomfort and failure to successfully refit. Data were collected from clinical charts. Data from 50 matched healthy volunteers served as controls. Clinical tests included subjective discomfort symptoms questionnaire (Ocular Surface Disease Index, OSDI), Schirmer test, break-up time (BUT), corneal esthesiometry and corneo-conjunctival staining. Laboratory tests included scraping and imprint cytology. Tear protein analysis included dosage of total tear protein (TP), lysozyme-C (LYS-C), lactoferrin (LACTO), zinc-α2-glycoprotein (ZAG-2), IgA heavy chain bands (Ig-A), and serum albumin (ALB). Data were correlated to wear parameters. Results: All values were significantly worse in intolerant CL wearers group (p always

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Publication statusAccepted/In press - Jun 9 2016


  • Contact lens
  • Discontinuation
  • Ocular surface
  • Tear proteins

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Intolerant contact lens wearers exhibit ocular surface impairment despite 3 months wear discontinuation'. Together they form a unique fingerprint.

Cite this