Intra- and inter-observer variability in measuring lesion volume changes on serial brain MRI scans in patients with multiple sclerosis

M. Filippi, M. Rovaris, M. P. Sormani, G. Mastronardo, M. A. Rocca, G. Comi

Research output: Contribution to journalArticlepeer-review

Abstract

This study evaluated the intra- and inter-observer variabilities when measuring long-term changes of multiple sclerosis (MS) brain lesion volumes on magnetic resonance imaging (MRI) scans with both 5 mm and 3 mm thick slices. We scanned 18 patients on two separate occasions with a mean interval 16.4 months between the two examinations. In each scanning session, a scan with 24 contiguous 5 mm thick and another with 40 contiguous 3 mm thick axial slices were acquired consecutively without moving the patient from the scanner. We assessed MRI lesion loads using a semi-automated local thresholding technique. Lesion volumes were significantly higher on scans with 3 mm thick slices than on those with 5 mm thick slices both at baseline and at follow up (p <0.001). Significant increases in the total lesion volume were observed during the follow up period on scans with 5 mm (median difference=+3.1%, range=53.7%-+49.2%; p=0.003) and on those with 3 mm (median difference=+4.5%, range=-46.2%-+41.9%; p=0.003) thick slices. The intra-observer (p <0.001) and the inter-observer (p-

Original languageEnglish
Pages (from-to)137
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Intra- and inter-observer variability in measuring lesion volume changes on serial brain MRI scans in patients with multiple sclerosis'. Together they form a unique fingerprint.

Cite this