Intra-arterial ACNU and carboplatin versus intravenous chemotherapy with cisplatin and BCNU in newly diagnosed patients with glioblastoma

A. Silvani, M. Eoli, A. Salmaggi, A. Erbetta, L. Fariselli, A. Boiardi

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Abstract

Thirty glioblastoma patients treated at our institute between April 1998 and September 1999 were randomized in a two-arm study to receive carboplatin plus ACNU intra-arterial (IA) chemotherapy (arm A) or cisplatin plus BCNU intravenous (IV) treatment (arm B). After the second course of chemotherapy and before the third cycle they also received concomitant radiotherapy, consisting of a median dose of 56.5 Gy. There were 3 (21.4%) partial responses and 11 (78.6%) disease stabilizations in group A. There were 5 (33%) partial responses and 10 disease stabilizations in group B. Time to tumor progression was 5.2 and 5.8 months for IA and IV treatment respectively. Median survival time was 18.3 months for arm A patients and 18.6 for arm B patients. Our IA chemotherapy schedule has produced no conclusive evidence of benefit compared with intravenous treatment. Morever, its cost-benefit ratio is not good enough to justify its continued pursuit.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalNeurological Sciences
Volume23
Issue number5
DOIs
Publication statusPublished - Dec 2002

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Keywords

  • ACNU
  • Carboplatin
  • Cisplatin
  • Glioblastoma
  • Intra-arterial chemotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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