Intra-arterial chemotherapy for liver metastases from colorectal cancer.

M. Milandri, F. Calzolari, A. Passardi, R. Ridolfi, C. Tison, E. Giampalma, R. Golfieri, L. Ridolfi, G. Mura, A. Vagliasindi, M. Fra Marini, G. M. Verdecchia

Research output: Chapter in Book/Report/Conference proceedingChapter


The aim was to investigate whether intra-arterial infusion of chemotherapy improves response to treatment in unresectable liver metastases from colorectal cancer. We treated 14 patients (pts) with intra-arterial chemotherapy. Arterial catheters were placed via percutaneous access. Treatment schedule was: 5-FU and mitomycin-C on day 1 every 21 days. Six pts also received from day 3 for 5 days, a continuous intra-arterial 24-hr infusion of interleukin-2 (IL-2). We had only one case of toxicity drug-related > grade 2 (neutropenia). We observed 2 partial response (PR) and 5 stable disease (SD). Median time to disease progression (TTP) and median survival (OS) were, respectively 4 and 15 months.

Original languageEnglish
Title of host publicationI supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
Publication statusPublished - 2005

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