Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma: Case report and review of the literature

L. Moscetti, R. Saltarelli, R. Giuliani, G. Fornarini, M. Bezzi, E. Cortesi

Research output: Contribution to journalArticle

Abstract

Background: Malignant insulinoma is a rare tumor. Metastatic disease confined to the liver can be treated with various locoregional treatments. Case report: We report a case of a young woman who developed liver metastases twelve years following resection of a pancreatic insulinoma positive to anti-insulin antibodies. With five cycles of intra-arterial locoregional chemotherapy (fluorouracil and epirubicin) to the liver and monthly hormone therapy (octreotide) the patient obtained a clinical complete response. After twelve months she is still disease free. Conclusion: Locoregional therapy for insulinoma metastatic to the liver might represent the treatment of choice; hepatic intra-arterial chemotherapy is an interesting therapeutic approach which deserves attention. The role of somatostatin analogs is limited to symptom control.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalTumori
Volume86
Issue number6
Publication statusPublished - 2000

Fingerprint

Insulinoma
Hormones
Drug Therapy
Liver
Insulin Antibodies
Therapeutics
Epirubicin
Octreotide
Somatostatin
Fluorouracil
Anti-Idiotypic Antibodies
Neoplasm Metastasis
Neoplasms

Keywords

  • Insulinoma
  • Intra-arterial chemotherapy
  • Liver metastasis

ASJC Scopus subject areas

  • Cancer Research

Cite this

Moscetti, L., Saltarelli, R., Giuliani, R., Fornarini, G., Bezzi, M., & Cortesi, E. (2000). Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma: Case report and review of the literature. Tumori, 86(6), 475-479.

Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma : Case report and review of the literature. / Moscetti, L.; Saltarelli, R.; Giuliani, R.; Fornarini, G.; Bezzi, M.; Cortesi, E.

In: Tumori, Vol. 86, No. 6, 2000, p. 475-479.

Research output: Contribution to journalArticle

Moscetti, L, Saltarelli, R, Giuliani, R, Fornarini, G, Bezzi, M & Cortesi, E 2000, 'Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma: Case report and review of the literature', Tumori, vol. 86, no. 6, pp. 475-479.
Moscetti, L. ; Saltarelli, R. ; Giuliani, R. ; Fornarini, G. ; Bezzi, M. ; Cortesi, E. / Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma : Case report and review of the literature. In: Tumori. 2000 ; Vol. 86, No. 6. pp. 475-479.
@article{283c1f6bd4d34e96a1ff8909fcd1ff8a,
title = "Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma: Case report and review of the literature",
abstract = "Background: Malignant insulinoma is a rare tumor. Metastatic disease confined to the liver can be treated with various locoregional treatments. Case report: We report a case of a young woman who developed liver metastases twelve years following resection of a pancreatic insulinoma positive to anti-insulin antibodies. With five cycles of intra-arterial locoregional chemotherapy (fluorouracil and epirubicin) to the liver and monthly hormone therapy (octreotide) the patient obtained a clinical complete response. After twelve months she is still disease free. Conclusion: Locoregional therapy for insulinoma metastatic to the liver might represent the treatment of choice; hepatic intra-arterial chemotherapy is an interesting therapeutic approach which deserves attention. The role of somatostatin analogs is limited to symptom control.",
keywords = "Insulinoma, Intra-arterial chemotherapy, Liver metastasis",
author = "L. Moscetti and R. Saltarelli and R. Giuliani and G. Fornarini and M. Bezzi and E. Cortesi",
year = "2000",
language = "English",
volume = "86",
pages = "475--479",
journal = "Tumori",
issn = "0300-8916",
publisher = "SAGE Publications Ltd",
number = "6",

}

TY - JOUR

T1 - Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma

T2 - Case report and review of the literature

AU - Moscetti, L.

AU - Saltarelli, R.

AU - Giuliani, R.

AU - Fornarini, G.

AU - Bezzi, M.

AU - Cortesi, E.

PY - 2000

Y1 - 2000

N2 - Background: Malignant insulinoma is a rare tumor. Metastatic disease confined to the liver can be treated with various locoregional treatments. Case report: We report a case of a young woman who developed liver metastases twelve years following resection of a pancreatic insulinoma positive to anti-insulin antibodies. With five cycles of intra-arterial locoregional chemotherapy (fluorouracil and epirubicin) to the liver and monthly hormone therapy (octreotide) the patient obtained a clinical complete response. After twelve months she is still disease free. Conclusion: Locoregional therapy for insulinoma metastatic to the liver might represent the treatment of choice; hepatic intra-arterial chemotherapy is an interesting therapeutic approach which deserves attention. The role of somatostatin analogs is limited to symptom control.

AB - Background: Malignant insulinoma is a rare tumor. Metastatic disease confined to the liver can be treated with various locoregional treatments. Case report: We report a case of a young woman who developed liver metastases twelve years following resection of a pancreatic insulinoma positive to anti-insulin antibodies. With five cycles of intra-arterial locoregional chemotherapy (fluorouracil and epirubicin) to the liver and monthly hormone therapy (octreotide) the patient obtained a clinical complete response. After twelve months she is still disease free. Conclusion: Locoregional therapy for insulinoma metastatic to the liver might represent the treatment of choice; hepatic intra-arterial chemotherapy is an interesting therapeutic approach which deserves attention. The role of somatostatin analogs is limited to symptom control.

KW - Insulinoma

KW - Intra-arterial chemotherapy

KW - Liver metastasis

UR - http://www.scopus.com/inward/record.url?scp=0034494307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034494307&partnerID=8YFLogxK

M3 - Article

C2 - 11218190

AN - SCOPUS:0034494307

VL - 86

SP - 475

EP - 479

JO - Tumori

JF - Tumori

SN - 0300-8916

IS - 6

ER -