Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma: Case report and review of the literature

L. Moscetti, R. Saltarelli, R. Giuliani, G. Fornarini, M. Bezzi, E. Cortesi

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Abstract

Background: Malignant insulinoma is a rare tumor. Metastatic disease confined to the liver can be treated with various locoregional treatments. Case report: We report a case of a young woman who developed liver metastases twelve years following resection of a pancreatic insulinoma positive to anti-insulin antibodies. With five cycles of intra-arterial locoregional chemotherapy (fluorouracil and epirubicin) to the liver and monthly hormone therapy (octreotide) the patient obtained a clinical complete response. After twelve months she is still disease free. Conclusion: Locoregional therapy for insulinoma metastatic to the liver might represent the treatment of choice; hepatic intra-arterial chemotherapy is an interesting therapeutic approach which deserves attention. The role of somatostatin analogs is limited to symptom control.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalTumori
Volume86
Issue number6
Publication statusPublished - 2000

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Keywords

  • Insulinoma
  • Intra-arterial chemotherapy
  • Liver metastasis

ASJC Scopus subject areas

  • Cancer Research

Cite this

Moscetti, L., Saltarelli, R., Giuliani, R., Fornarini, G., Bezzi, M., & Cortesi, E. (2000). Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma: Case report and review of the literature. Tumori, 86(6), 475-479.