Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy

Bianchi Roberto, Lombardi Raffaella, Porretta Serapiglia Carla, Lauria Giuseppe

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Small-diameter nervefibers, which subserve nociception, can be affected early in peripheral neuropathies, although their injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable tool to examine nonmyelinated nervefibers, as assessed by the quantification of intra-epidermal nervefiber (IENF) density not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy such as erythropoietin (EPO) treatment.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages197-211
Number of pages15
Volume982
ISBN (Print)9781627033077
DOIs
Publication statusPublished - 2013

Publication series

NameMethods in Molecular Biology
Volume982
ISSN (Print)10643745

Keywords

  • Diabetes
  • Diabetic neuropathy
  • Epidermal nerve fibers
  • Erythropoietin
  • PGP 9.5
  • Skin

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

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  • Cite this

    Roberto, B., Raffaella, L., Carla, P. S., & Giuseppe, L. (2013). Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy. In Methods in Molecular Biology (Vol. 982, pp. 197-211). (Methods in Molecular Biology; Vol. 982). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-308-4_13