Abstract
Small-diameter nervefibers, which subserve nociception, can be affected early in peripheral neuropathies, although their injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable tool to examine nonmyelinated nervefibers, as assessed by the quantification of intra-epidermal nervefiber (IENF) density not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy such as erythropoietin (EPO) treatment.
| Original language | English |
|---|---|
| Title of host publication | Methods in Molecular Biology |
| Publisher | Humana Press Inc. |
| Pages | 197-211 |
| Number of pages | 15 |
| Volume | 982 |
| ISBN (Print) | 9781627033077 |
| DOIs | |
| Publication status | Published - 2013 |
Publication series
| Name | Methods in Molecular Biology |
|---|---|
| Volume | 982 |
| ISSN (Print) | 10643745 |
Keywords
- Diabetes
- Diabetic neuropathy
- Epidermal nerve fibers
- Erythropoietin
- PGP 9.5
- Skin
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Medicine(all)
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Cite this
Roberto, B., Raffaella, L., Carla, P. S., & Giuseppe, L. (2013). Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy. In Methods in Molecular Biology (Vol. 982, pp. 197-211). (Methods in Molecular Biology; Vol. 982). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-308-4_13