Intra-hepatic levels of mRNA for IFN-α, IFN-γ, IFN type 1 receptor (IFNAR-1) and PKR were determined in hepatitis C virus (HCV)/HIV co-infected and HCV mono-infected patients. In co-infected patients, IFN-α mRNA was upregulated and correlated with HIV-1 viraemia. IFN-γ, IFNAR-1 and PKR mRNA were detected in mono-infected, but not in co-infected patients. These findings suggest that in HCV/HIV co-infected individuals the ability to respond to IFN-α is impaired, probably because of the absence of its receptor.
ASJC Scopus subject areas
- Immunology and Allergy