Intra-hepatic messenger RNA levels for interferons and related genes in hepatitis C virus/HIV co-infected patients

Isabella Abbate, Giuseppina Cappiello, Silvia Rosati, Guido Tocci, Giorgio Antonucci, Mariacarmela Solmone, Roberta Longo, Alberto Spanò, Maria Rosaria Capobianchi

Research output: Contribution to journalArticle

Abstract

Intra-hepatic levels of mRNA for IFN-α, IFN-γ, IFN type 1 receptor (IFNAR-1) and PKR were determined in hepatitis C virus (HCV)/HIV co-infected and HCV mono-infected patients. In co-infected patients, IFN-α mRNA was upregulated and correlated with HIV-1 viraemia. IFN-γ, IFNAR-1 and PKR mRNA were detected in mono-infected, but not in co-infected patients. These findings suggest that in HCV/HIV co-infected individuals the ability to respond to IFN-α is impaired, probably because of the absence of its receptor.

Original languageEnglish
Pages (from-to)691-692
Number of pages2
JournalAIDS (London, England)
Volume18
Issue number4
DOIs
Publication statusPublished - Mar 5 2004

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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