Intra-host genetic heterogeneity of hepatitis C virus and biomedical implications

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Abstract

The HCV genome exhibits significant intra-host genetic heterogeneity as the result of accumulation of mutations during viral replication. At each point in time during the infection, the viral population is composed of a dominant master sequence and a number of sequences diverging from the master sequence to various extents (the viral quasispecies). The quasispecies is a complex, dynamic distribution of nonidentical, but related, replicons. In these populations, viral variants may undergo very large changes in their fitness (the replicative adaptability of an organism to its environment), including dramatic fitness loss and important fitness gains. The biological impact of this event may theoretically include modifications of tropism, appearance of escape mutants, changes in pathogenic potential, and resistance to antiviral agents. A growing body of molecular and clinical data currently suggests that both inter- and intra-host genetic heterogeneity of HCV have crucial biological and medical implications, influencing not only infection prevention, but also clinical progression of chronic liver disease in persistently infected subjects, HCV infection of non-liver cells, and response to the anti-viral therapy.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume17
Issue number2
Publication statusPublished - Apr 2003

Fingerprint

Hepatitis C virus
Genetic Heterogeneity
Hepacivirus
Replicon
Tropism
Virus Diseases
Infection
infection
antiviral agents
Population
Antiviral Agents
Liver Diseases
replicon
tropisms
Chronic Disease
liver diseases
Genome
virus replication
pathogenicity
mutation

Keywords

  • Evolution
  • Hepatitis C virus
  • Intra-host HCV diversity
  • Viral fitness
  • Viral quasispecies

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

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