Abstract
New magnetic resonance (MR) measures considered to be putative markers of demyelination and axonal loss were found to be more closely related to clinical disability than T2-weighted MR imaging (MRI) findings in patients with multiple sclerosis (MS). In this study, we evaluated the reproducibility of such measurements in order to assess their reliability for longitudinal studies in MS. The intra-observer coefficients of variation for repeated measurements did not significantly differ among the MR techniques studied [2.6% for T2-weighted MRI, 4.38% for unenhanced T1-weighted MRI, 3.65% for magnetisation transfer imaging (MTI) and 2.28% for spinal cord cross-sectional area at C5]. Our findings suggest that non-conventional MR techniques may be reliable outcome measures for clinical trials in MS.
| Original language | English |
|---|---|
| Pages (from-to) | 266-270 |
| Number of pages | 5 |
| Journal | Journal of Neurology |
| Volume | 244 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1997 |
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Keywords
- Magnetic resonance imaging
- Magnetisation tranfer imaging
- Measurement reproducibility
- Multiple sclerosis
- Spinal cord
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis : A comparison with conventional T2-weighted images. / Rovaris, Marco; Filippi, Massimo; Calori, Giliola; Rodegher, Mariemma; Campi, Adriana; Colombo, Bruno; Comi, Giancarlo.
In: Journal of Neurology, Vol. 244, No. 4, 1997, p. 266-270.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis
T2 - A comparison with conventional T2-weighted images
AU - Rovaris, Marco
AU - Filippi, Massimo
AU - Calori, Giliola
AU - Rodegher, Mariemma
AU - Campi, Adriana
AU - Colombo, Bruno
AU - Comi, Giancarlo
PY - 1997
Y1 - 1997
N2 - New magnetic resonance (MR) measures considered to be putative markers of demyelination and axonal loss were found to be more closely related to clinical disability than T2-weighted MR imaging (MRI) findings in patients with multiple sclerosis (MS). In this study, we evaluated the reproducibility of such measurements in order to assess their reliability for longitudinal studies in MS. The intra-observer coefficients of variation for repeated measurements did not significantly differ among the MR techniques studied [2.6% for T2-weighted MRI, 4.38% for unenhanced T1-weighted MRI, 3.65% for magnetisation transfer imaging (MTI) and 2.28% for spinal cord cross-sectional area at C5]. Our findings suggest that non-conventional MR techniques may be reliable outcome measures for clinical trials in MS.
AB - New magnetic resonance (MR) measures considered to be putative markers of demyelination and axonal loss were found to be more closely related to clinical disability than T2-weighted MR imaging (MRI) findings in patients with multiple sclerosis (MS). In this study, we evaluated the reproducibility of such measurements in order to assess their reliability for longitudinal studies in MS. The intra-observer coefficients of variation for repeated measurements did not significantly differ among the MR techniques studied [2.6% for T2-weighted MRI, 4.38% for unenhanced T1-weighted MRI, 3.65% for magnetisation transfer imaging (MTI) and 2.28% for spinal cord cross-sectional area at C5]. Our findings suggest that non-conventional MR techniques may be reliable outcome measures for clinical trials in MS.
KW - Magnetic resonance imaging
KW - Magnetisation tranfer imaging
KW - Measurement reproducibility
KW - Multiple sclerosis
KW - Spinal cord
UR - http://www.scopus.com/inward/record.url?scp=0031004965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031004965&partnerID=8YFLogxK
U2 - 10.1007/s004150050083
DO - 10.1007/s004150050083
M3 - Article
VL - 244
SP - 266
EP - 270
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 4
ER -