Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis: A comparison with conventional T2-weighted images

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Abstract

New magnetic resonance (MR) measures considered to be putative markers of demyelination and axonal loss were found to be more closely related to clinical disability than T2-weighted MR imaging (MRI) findings in patients with multiple sclerosis (MS). In this study, we evaluated the reproducibility of such measurements in order to assess their reliability for longitudinal studies in MS. The intra-observer coefficients of variation for repeated measurements did not significantly differ among the MR techniques studied [2.6% for T2-weighted MRI, 4.38% for unenhanced T1-weighted MRI, 3.65% for magnetisation transfer imaging (MTI) and 2.28% for spinal cord cross-sectional area at C5]. Our findings suggest that non-conventional MR techniques may be reliable outcome measures for clinical trials in MS.

Original languageEnglish
Pages (from-to)266-270
Number of pages5
JournalJournal of Neurology
Volume244
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Magnetic resonance imaging
  • Magnetisation tranfer imaging
  • Measurement reproducibility
  • Multiple sclerosis
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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