Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis

A comparison with conventional T2-weighted images

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154 Citations (Scopus)

Abstract

New magnetic resonance (MR) measures considered to be putative markers of demyelination and axonal loss were found to be more closely related to clinical disability than T2-weighted MR imaging (MRI) findings in patients with multiple sclerosis (MS). In this study, we evaluated the reproducibility of such measurements in order to assess their reliability for longitudinal studies in MS. The intra-observer coefficients of variation for repeated measurements did not significantly differ among the MR techniques studied [2.6% for T2-weighted MRI, 4.38% for unenhanced T1-weighted MRI, 3.65% for magnetisation transfer imaging (MTI) and 2.28% for spinal cord cross-sectional area at C5]. Our findings suggest that non-conventional MR techniques may be reliable outcome measures for clinical trials in MS.

Original languageEnglish
Pages (from-to)266-270
Number of pages5
JournalJournal of Neurology
Volume244
Issue number4
DOIs
Publication statusPublished - 1997

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Demyelinating Diseases
Multiple Sclerosis
Magnetic Resonance Spectroscopy
Observer Variation
Longitudinal Studies
Spinal Cord
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Clinical Trials

Keywords

  • Magnetic resonance imaging
  • Magnetisation tranfer imaging
  • Measurement reproducibility
  • Multiple sclerosis
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

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title = "Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis: A comparison with conventional T2-weighted images",
abstract = "New magnetic resonance (MR) measures considered to be putative markers of demyelination and axonal loss were found to be more closely related to clinical disability than T2-weighted MR imaging (MRI) findings in patients with multiple sclerosis (MS). In this study, we evaluated the reproducibility of such measurements in order to assess their reliability for longitudinal studies in MS. The intra-observer coefficients of variation for repeated measurements did not significantly differ among the MR techniques studied [2.6{\%} for T2-weighted MRI, 4.38{\%} for unenhanced T1-weighted MRI, 3.65{\%} for magnetisation transfer imaging (MTI) and 2.28{\%} for spinal cord cross-sectional area at C5]. Our findings suggest that non-conventional MR techniques may be reliable outcome measures for clinical trials in MS.",
keywords = "Magnetic resonance imaging, Magnetisation tranfer imaging, Measurement reproducibility, Multiple sclerosis, Spinal cord",
author = "Marco Rovaris and Massimo Filippi and Giliola Calori and Mariemma Rodegher and Adriana Campi and Bruno Colombo and Giancarlo Comi",
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T1 - Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis

T2 - A comparison with conventional T2-weighted images

AU - Rovaris, Marco

AU - Filippi, Massimo

AU - Calori, Giliola

AU - Rodegher, Mariemma

AU - Campi, Adriana

AU - Colombo, Bruno

AU - Comi, Giancarlo

PY - 1997

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N2 - New magnetic resonance (MR) measures considered to be putative markers of demyelination and axonal loss were found to be more closely related to clinical disability than T2-weighted MR imaging (MRI) findings in patients with multiple sclerosis (MS). In this study, we evaluated the reproducibility of such measurements in order to assess their reliability for longitudinal studies in MS. The intra-observer coefficients of variation for repeated measurements did not significantly differ among the MR techniques studied [2.6% for T2-weighted MRI, 4.38% for unenhanced T1-weighted MRI, 3.65% for magnetisation transfer imaging (MTI) and 2.28% for spinal cord cross-sectional area at C5]. Our findings suggest that non-conventional MR techniques may be reliable outcome measures for clinical trials in MS.

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KW - Spinal cord

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