Intra-oral administration of sweet-tasting substances and infants' crying response to immunization: A randomized, placebo-controlled trial

Luca A. Ramenghi, A. Vivian Webb, Patricia M. Shevlin, Martine Green, David J. Evans, Malcolm I. Levene

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The analgesic effects of four solutions administered intra-orally (25 and 50% sucrose solutions, hydrogenated glucose, and a sterile water placebo) were tested in groups of babies receiving routine DTP (diphtheria, tetanus, and pertussis) and HIB (Haemophilus influenzae type B) injections at the first, second, or third immunization. The duration of the baby's cry during 3 min following DTP and HIB injections was measured as main outcome. For all three immunization groups, the babies receiving the placebo generally spent most time crying. For both the DTP and HIB injections, the difference between 50% sucrose and placebo was most evident in the group receiving the 3rd immunization. Intra-oral administration of the 50% sucrose solution, compared to placebo, appeared to reduce the cry response to painful experiences in babies beyond the neonatal period.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalBiology of the Neonate
Volume81
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Crying
Diphtheria
Oral Administration
Whooping Cough
Immunization
Haemophilus influenzae
Tetanus
Randomized Controlled Trials
Placebos
Sucrose
Injections
Analgesics
Glucose
Water

Keywords

  • Cry, infant
  • Glucose
  • Immunization
  • Nociception
  • Pain response
  • Sucrose

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Intra-oral administration of sweet-tasting substances and infants' crying response to immunization : A randomized, placebo-controlled trial. / Ramenghi, Luca A.; Webb, A. Vivian; Shevlin, Patricia M.; Green, Martine; Evans, David J.; Levene, Malcolm I.

In: Biology of the Neonate, Vol. 81, No. 3, 2002, p. 163-169.

Research output: Contribution to journalArticle

Ramenghi, Luca A. ; Webb, A. Vivian ; Shevlin, Patricia M. ; Green, Martine ; Evans, David J. ; Levene, Malcolm I. / Intra-oral administration of sweet-tasting substances and infants' crying response to immunization : A randomized, placebo-controlled trial. In: Biology of the Neonate. 2002 ; Vol. 81, No. 3. pp. 163-169.
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