Intra-voxel and inter-voxel coherence in patients with multiple sclerosis assessed using diffusion tensor MRI

Research output: Contribution to journalArticle


Previous diffusion tensor magnetic resonance imaging (DT-MRI) studies reported mean diffusivity (D̄) and fractional anisotropy (FA) changes in lesions and normal-appearing white matter (NAWM) of patients with multiple sclerosis (MS), but neglected the additional information which can be obtained by the analysis of the inter-voxel coherence (C). The present study is based on a large sample of patients with MS and it is aimed at assessing the potential role of C in the quantification of MS-related tissue damage of T2-visible lesions and NAWM. We obtained dual-echo, T1-weighted and DT-MRI scans from 78 patients with relapsing-remitting (RR), secondary progressive (SP), or primary progressive (PP) MS and from 26 healthy volunteers. We calculated D̄, FA and C of T2-hyperintense lesions, T1-isointense lesions, T1-hypointense lesions and several areas of the NAWM. D̄ and FA of the majority of NAWM regions studied from MS patients were different from the corresponding quantities of the white matter from controls. NAWM C from patients was lower than white matter C from controls only for the parietal pericallosal areas. SPMS patients had higher corpus callosum D̄ and lower corpus callosum FA and C than patients with either RRMS or PPMS. Average lesion D̄ was higher, and average FA and C lower than the corresponding quantities measured in the NAWM. Average T1-hypointense lesion D̄ was higher and average FA lower than the corresponding quantities of T1-isointense lesions, whereas average C of these two lesion populations were not different. SPMS had higher average lesion D̄ than both PPMS and RRMS patients. NAWM D̄ and C of the corpus callosum were moderately correlated with disability. This study confirms the role of DT-MRI metrics to identify MS lesions with different amounts of tissue damage and to detect diffuse changes in the NAWM. It also shows that measuring C enables us to obtain additional information about tissue damage, which is complementary to that given by the analysis of D̄ and FA.

Original languageEnglish
Pages (from-to)875-883
Number of pages9
JournalJournal of Neurology
Issue number7
Publication statusPublished - 2002


  • Diffusion Tensor MRI
  • Magnetic Resonance Imaging
  • Multiple Sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'Intra-voxel and inter-voxel coherence in patients with multiple sclerosis assessed using diffusion tensor MRI'. Together they form a unique fingerprint.

  • Cite this