Intracellular bacteria can cause EAE in SJL mice or modify self-specific T cell repertoire

Chiara Nicolò, Gabriele Di Sante, Giuseppe Migliara, Maria Grazia Valentini, Alessia Piermattei, Giovanni Delogu, Francesco Ria

Research output: Contribution to journalArticlepeer-review

Abstract

Environment and genetic are both relevant in determining development of Multiple Sclerosis. Many epidemiological observations converge on indicating EBV infection and Vitamin D levels as major players among the environmental factors. Bacteria and bacterial products are however potent triggers of immune responses, and recent work from several laboratories indicates that the microbiota plays a prominent role in "priming" or protecting individuals for development of experimental autoimmune diseases. Here we report our recent work dealing with the role of non-pathogenic mycobacteria and their innate receptors in relapsing-remitting experimental autoimmune encephalomyelitis in the SJL mouse and in mobilization of CNS-reactive T cells. We finally discuss how bacteria are likely involved in the pathogenesis of Multiple Sclerosis, expecially with regard to their role in driving the recurring acute episodes of disease.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalJournal of the Neurological Sciences
Volume311
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2011

Keywords

  • EAE
  • Mycobacterium
  • PLP
  • T cell recirculation
  • TCR
  • TLR

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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