Abstract
A 25-year-old man had complained of sudden fever spikes for two years and his blood tests were within the normal range. In 1993, a surgical biopsy of swollen left inguinal lymph nodes was negative for malignancy, but showed reactive lymphadenitis and widespread sinus histiocytosis. A concomitant needle biopsy of the periaortic lymph nodes and a bone marrow aspirate were also negative. In 1994, after an emergency hospital admission because of a sportrelated thoracic trauma, a right inguinal lymph node biopsy demonstrated Hodgkin's lymphoma Stage IVB (scleronodular mixed cell subtype). Although it was improved by chemotherapy, the disease suddenly relapsed, and a further lymph node biopsy was performed in 1998 confirming the same diagnosis. Despite further treatment, the patient died of septic shock in 2004, at the age of 38 years. Retrospective analysis of the various specimens showed intracellular heavy metal nanoparticles within lymph node, bone marrow, and liver samples by field emission gun environmental scanning electron microscopy and energy dispersive spectroscopy. Heavy metals from environmental pollution may accumulate in sites far from the entry route and, in genetically conditioned individuals with tissue specificity, may act as cofactors for chronic inflammation or even malignant transformation. The present anecdotal report highlights the need for further pathologic ultrastructural investigations using serial samples and the possible role of intracellular nanoparticles in human disease.
| Original language | English |
|---|---|
| Pages (from-to) | 955-960 |
| Number of pages | 6 |
| Journal | International Journal of Nanomedicine |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Environmental exposure
- Heavy metals
- Hodgkin's lymphoma
- Host-particle interactions
- Nanoparticles
- Nanotoxicity
ASJC Scopus subject areas
- Biophysics
- Bioengineering
- Biomaterials
- Organic Chemistry
- Drug Discovery
Cite this
Intracellular heavy metal nanoparticle storage : Progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy. / Iannitti, Tommaso; Capone, Stefania; Gatti, Antonietta; Capitani, Frederico; Cetta, Francesco; Palmieri, Beniamino.
In: International Journal of Nanomedicine, Vol. 5, No. 1, 2010, p. 955-960.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intracellular heavy metal nanoparticle storage
T2 - Progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy
AU - Iannitti, Tommaso
AU - Capone, Stefania
AU - Gatti, Antonietta
AU - Capitani, Frederico
AU - Cetta, Francesco
AU - Palmieri, Beniamino
PY - 2010
Y1 - 2010
N2 - A 25-year-old man had complained of sudden fever spikes for two years and his blood tests were within the normal range. In 1993, a surgical biopsy of swollen left inguinal lymph nodes was negative for malignancy, but showed reactive lymphadenitis and widespread sinus histiocytosis. A concomitant needle biopsy of the periaortic lymph nodes and a bone marrow aspirate were also negative. In 1994, after an emergency hospital admission because of a sportrelated thoracic trauma, a right inguinal lymph node biopsy demonstrated Hodgkin's lymphoma Stage IVB (scleronodular mixed cell subtype). Although it was improved by chemotherapy, the disease suddenly relapsed, and a further lymph node biopsy was performed in 1998 confirming the same diagnosis. Despite further treatment, the patient died of septic shock in 2004, at the age of 38 years. Retrospective analysis of the various specimens showed intracellular heavy metal nanoparticles within lymph node, bone marrow, and liver samples by field emission gun environmental scanning electron microscopy and energy dispersive spectroscopy. Heavy metals from environmental pollution may accumulate in sites far from the entry route and, in genetically conditioned individuals with tissue specificity, may act as cofactors for chronic inflammation or even malignant transformation. The present anecdotal report highlights the need for further pathologic ultrastructural investigations using serial samples and the possible role of intracellular nanoparticles in human disease.
AB - A 25-year-old man had complained of sudden fever spikes for two years and his blood tests were within the normal range. In 1993, a surgical biopsy of swollen left inguinal lymph nodes was negative for malignancy, but showed reactive lymphadenitis and widespread sinus histiocytosis. A concomitant needle biopsy of the periaortic lymph nodes and a bone marrow aspirate were also negative. In 1994, after an emergency hospital admission because of a sportrelated thoracic trauma, a right inguinal lymph node biopsy demonstrated Hodgkin's lymphoma Stage IVB (scleronodular mixed cell subtype). Although it was improved by chemotherapy, the disease suddenly relapsed, and a further lymph node biopsy was performed in 1998 confirming the same diagnosis. Despite further treatment, the patient died of septic shock in 2004, at the age of 38 years. Retrospective analysis of the various specimens showed intracellular heavy metal nanoparticles within lymph node, bone marrow, and liver samples by field emission gun environmental scanning electron microscopy and energy dispersive spectroscopy. Heavy metals from environmental pollution may accumulate in sites far from the entry route and, in genetically conditioned individuals with tissue specificity, may act as cofactors for chronic inflammation or even malignant transformation. The present anecdotal report highlights the need for further pathologic ultrastructural investigations using serial samples and the possible role of intracellular nanoparticles in human disease.
KW - Environmental exposure
KW - Heavy metals
KW - Hodgkin's lymphoma
KW - Host-particle interactions
KW - Nanoparticles
KW - Nanotoxicity
UR - http://www.scopus.com/inward/record.url?scp=79954506036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954506036&partnerID=8YFLogxK
U2 - 10.2147/IJN.S14363
DO - 10.2147/IJN.S14363
M3 - Article
C2 - 21187947
AN - SCOPUS:79954506036
VL - 5
SP - 955
EP - 960
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
SN - 1176-9114
IS - 1
ER -