Intracellular metabolic pathways control immune tolerance

Claudio Procaccini, Mario Galgani, Veronica De Rosa, Giuseppe Matarese

Research output: Contribution to journalArticle

Abstract

Disorders such as obesity and type 2 diabetes have been linked to immune dysfunction, raising the possibility that metabolic alterations can be induced by or be a consequence of alterations in immunological tolerance. Here, we describe how intracellular metabolic signalling pathways can 'sense' host energy/nutritional status, and in response, modulate regulatory T (Treg) cell function. In particular, we focus on mammalian target of rapamycin (mTOR) signalling, and how stimuli such as nutrients and leptin activate mTOR in an oscillatory manner to determine Treg cell proliferation status. We propose that metabolic changes such as nutritional deprivation or overload could dictate the characteristics of the Treg cell compartment and subsequent downstream immune reactions.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalTrends in Immunology
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Immune Tolerance
Regulatory T-Lymphocytes
Metabolic Networks and Pathways
Sirolimus
Leptin
Nutritional Status
Type 2 Diabetes Mellitus
Obesity
Cell Proliferation
Food

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Intracellular metabolic pathways control immune tolerance. / Procaccini, Claudio; Galgani, Mario; De Rosa, Veronica; Matarese, Giuseppe.

In: Trends in Immunology, Vol. 33, No. 1, 01.2012, p. 1-7.

Research output: Contribution to journalArticle

Procaccini, Claudio ; Galgani, Mario ; De Rosa, Veronica ; Matarese, Giuseppe. / Intracellular metabolic pathways control immune tolerance. In: Trends in Immunology. 2012 ; Vol. 33, No. 1. pp. 1-7.
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