Intracellular NAD+ depletion induces autophagic death in multiple myeloma cells

Michele Cea, Antonia Cagnetta, Franco Patrone, Alessio Nencioni, Marco Gobbi, Kenneth C. Anderson

Research output: Contribution to journalArticle

Abstract

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by the proliferation of plasma cells in the bone marrow. Despite recent therapeutic advances, MM remains an incurable disease. Therefore, research has focused on defining new aspects in MM biology that can be therapeutically targeted. Compelling evidence suggests that malignant cells have a higher nicotinamide adenine dinucleotide (NAD+) turnover rate than normal cells, suggesting that this biosynthetic pathway represents an attractive target for cancer treatment. We recently reported that an intracellular NAD+-depleting agent, FK866, exerts its anti-MM effect by triggering autophagic cell death via transcriptional- dependent (transcription factor EB, TFEB) and -independent (PI3K-MTORC1) mechanisms. Our findings link intracellular NAD+ levels to autophagy in MM cells, providing the rationale for novel targeted therapies in MM.

Original languageEnglish
Pages (from-to)410-412
Number of pages3
JournalAutophagy
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Cancer Treatment
  • Multiple Myeloma
  • Nicotinamide Phosphoribosyltransferase
  • Pi3K/ Mtorc1
  • Tfeb

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Intracellular NAD<sup>+</sup> depletion induces autophagic death in multiple myeloma cells'. Together they form a unique fingerprint.

  • Cite this