TY - JOUR
T1 - Intracellular redox state as target for anti-influenza therapy
T2 - Are antioxidants always effective?
AU - Sgarbanti, Rossella
AU - Amatore, Donatella
AU - Celestino, Ignacio
AU - Marcocci, Maria Elena
AU - Fraternale, Alessandra
AU - Ciriolo, Maria Rosa
AU - Magnani, Mauro
AU - Saladino, Raffaele
AU - Garaci, Enrico
AU - Palamara, Anna Teresa
AU - Nencioni, Lucia
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Influenza virus infections represent a big issue for public health since effective treatments are still lacking. In particular, the emergence of strains resistant to drugs limits the effectiveness of anti-influenza agents. For this reason, many efforts have been dedicated to the identification of new therapeutic strategies aimed at targeting the virus-host cell interactions. Oxidative stress is a characteristic of some viral infections including influenza. Because antioxidants defend cells from damage caused by reactive oxygen species induced by different stimuli including pathogens, they represent interesting molecules to fight infectious diseases. However, most of the available studies have found that these would-be panaceas could actually exacerbate the diseases they claim to prevent, and have thus revealed "the dark side" of these molecules. This review article discusses the latest opportunities and drawbacks of the antioxidants used in anti-influenza therapy and new perspectives.
AB - Influenza virus infections represent a big issue for public health since effective treatments are still lacking. In particular, the emergence of strains resistant to drugs limits the effectiveness of anti-influenza agents. For this reason, many efforts have been dedicated to the identification of new therapeutic strategies aimed at targeting the virus-host cell interactions. Oxidative stress is a characteristic of some viral infections including influenza. Because antioxidants defend cells from damage caused by reactive oxygen species induced by different stimuli including pathogens, they represent interesting molecules to fight infectious diseases. However, most of the available studies have found that these would-be panaceas could actually exacerbate the diseases they claim to prevent, and have thus revealed "the dark side" of these molecules. This review article discusses the latest opportunities and drawbacks of the antioxidants used in anti-influenza therapy and new perspectives.
KW - Anti-influenza therapy
KW - Antioxidants
KW - Antivirals
KW - Influenza virus
KW - Oxidative stress
KW - Redox state
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M3 - Article
C2 - 25478883
AN - SCOPUS:84921857130
VL - 14
SP - 2529
EP - 2541
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
SN - 1568-0266
IS - 22
ER -