Intracellular responses of caudate neurons to brain stem stimulation

C. D. Hull, G. Bernardi, N. A. Buchwald

Research output: Contribution to journalArticlepeer-review

Abstract

Intracellular recordings were made of responses of caudate neurons to stimulation of substantia nigra and adjacent brain stem structures in cats. The locations of brain stem stimulating points which evoked responses in caudate neurons mapped a pathway generally similar to the dopaminergic nigro-striatal tract which was previously described by histochemical means. Lesions in the central median-parafascicular complex of the thalamus did not prevent these nigro-caudate responses from being elicited. Responses in caudate neurons to nigral and supranigral stimuli varied in form, but often included EPSP-IPSP sequences. In such cases the duration of the 'IPSP' was always shorter than those evoked in the same neurons by precruciate cortical stimulations or by anterior thalamic stimuli. Effects of stimulus intensity and frequency were assessed. Increases in stimulus intensity increased the amplitude, but not the duration of the intracellular membrane responses. Bursts of high frequency stimulation evoked poststimulus depolarizations of long duration. The possible significance of these long depolarizations for understanding the functions of caudate neurons was discussed.

Original languageEnglish
Pages (from-to)163-179
Number of pages17
JournalBrain Research
Volume22
Issue number2
DOIs
Publication statusPublished - Aug 27 1970

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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