Abstract
Multi-drug resistance (MDR) frequently contributes to the failure of chemotherapeutic treatments in cancer patients. Mechanisms underlying the development of MDR have been extensively studied and are considered multifactorial. Among them, the ATP-Binding Cassette (ABC) family of proteins plays a pivotal role. Processes of cellular distribution and subcellular localization of MDR-ABC proteins are not yet well explored and to enlighten these topics could be crucial to understand cellular drug uptake and retention. In this review, we analysed literature data concerning i) intracellular trafficking of MDR-ABC proteins (BCRP, P-gp and MRP1) and ii) mechanisms altering their cellular localization and trafficking. Moreover, we describe single nucleotide polymorphisms (SNP) that have been reported for some multidrug resistance (MDR) transporters, such as BCRP and P-gp, emphasizing their ability to affect the expression, function and localization of the transporters, with implications on drug resistance phenotypes.
| Original language | English |
|---|---|
| Pages (from-to) | 197-208 |
| Number of pages | 12 |
| Journal | Current Topics in Medicinal Chemistry |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- BCRP
- MDR
- MRP
- P-gP
- SNP
ASJC Scopus subject areas
- Drug Discovery
Cite this
Intracellular trafficking of MDR transporters and relevance of SNPs. / Porcelli, Letizia; Lemos, Clara; Peters, Godefridus J.; Paradiso, Angelo; Azzariti, Amalia.
In: Current Topics in Medicinal Chemistry, Vol. 9, No. 2, 2009, p. 197-208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intracellular trafficking of MDR transporters and relevance of SNPs
AU - Porcelli, Letizia
AU - Lemos, Clara
AU - Peters, Godefridus J.
AU - Paradiso, Angelo
AU - Azzariti, Amalia
PY - 2009
Y1 - 2009
N2 - Multi-drug resistance (MDR) frequently contributes to the failure of chemotherapeutic treatments in cancer patients. Mechanisms underlying the development of MDR have been extensively studied and are considered multifactorial. Among them, the ATP-Binding Cassette (ABC) family of proteins plays a pivotal role. Processes of cellular distribution and subcellular localization of MDR-ABC proteins are not yet well explored and to enlighten these topics could be crucial to understand cellular drug uptake and retention. In this review, we analysed literature data concerning i) intracellular trafficking of MDR-ABC proteins (BCRP, P-gp and MRP1) and ii) mechanisms altering their cellular localization and trafficking. Moreover, we describe single nucleotide polymorphisms (SNP) that have been reported for some multidrug resistance (MDR) transporters, such as BCRP and P-gp, emphasizing their ability to affect the expression, function and localization of the transporters, with implications on drug resistance phenotypes.
AB - Multi-drug resistance (MDR) frequently contributes to the failure of chemotherapeutic treatments in cancer patients. Mechanisms underlying the development of MDR have been extensively studied and are considered multifactorial. Among them, the ATP-Binding Cassette (ABC) family of proteins plays a pivotal role. Processes of cellular distribution and subcellular localization of MDR-ABC proteins are not yet well explored and to enlighten these topics could be crucial to understand cellular drug uptake and retention. In this review, we analysed literature data concerning i) intracellular trafficking of MDR-ABC proteins (BCRP, P-gp and MRP1) and ii) mechanisms altering their cellular localization and trafficking. Moreover, we describe single nucleotide polymorphisms (SNP) that have been reported for some multidrug resistance (MDR) transporters, such as BCRP and P-gp, emphasizing their ability to affect the expression, function and localization of the transporters, with implications on drug resistance phenotypes.
KW - BCRP
KW - MDR
KW - MRP
KW - P-gP
KW - SNP
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U2 - 10.2174/156802609787521562
DO - 10.2174/156802609787521562
M3 - Article
C2 - 19200005
AN - SCOPUS:63349112237
VL - 9
SP - 197
EP - 208
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
SN - 1568-0266
IS - 2
ER -