Abstract
Aim: To describe a spectrum of intracerebral large artery disease in Aicardi-Goutières syndrome (AGS) associated with mutations in the AGS5 gene SAMHD1. Method: We used clinical and radiological description and molecular analysis. Results: Five individuals (three males, two females) were identified as having biallelic mutations in SAMHD1 and a cerebral arteriopathy in association with peripheral vessel involvement resulting in chilblains and ischaemic ulceration. The cerebral vasculopathy was primarily occlusive in three patients (with terminal carotid occlusion and basal collaterals reminiscent of moyamoya syndrome) and aneurysmal in two. Three of the five patients experienced intracerebral haemorrhage, which was fatal in two individuals. Post-mortem examination of one patient suggested that the arteriopathy was inflammatory in origin. Interpretation: Mutations in SAMHD1 are associated with a cerebral vasculopathy which is likely to have an inflammatory aetiology. A similar disease has not been observed in patients with mutations in AGS1 to AGS4, suggesting a particular role for SAMHD1 in vascular homeostasis. Our report raises important questions about the management of patients with mutations in SAMHD1.
| Original language | English |
|---|---|
| Pages (from-to) | 725-732 |
| Number of pages | 8 |
| Journal | Developmental Medicine and Child Neurology |
| Volume | 52 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2010 |
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ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Developmental Neuroscience
Cite this
Intracerebral large artery disease in Aicardi-Goutières syndrome implicates SAMHD1 in vascular homeostasis. / Ramesh, Venkateswaran; Bernardi, Bruno; Stafa, Altin; Garone, Caterina; Franzoni, Emilio; Abinun, Mario; Mitchell, Patrick; Mitra, Dipayan; Friswell, Mark; Nelson, John; Shalev, Stavit A.; Rice, Gillian I.; Gornall, Hannah; Szynkiewicz, Marcin; Aymard, François; Ganesan, Vijeya; Prendiville, Julie; Livingston, John H.; Crow, Yanick J.
In: Developmental Medicine and Child Neurology, Vol. 52, No. 8, 08.2010, p. 725-732.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intracerebral large artery disease in Aicardi-Goutières syndrome implicates SAMHD1 in vascular homeostasis
AU - Ramesh, Venkateswaran
AU - Bernardi, Bruno
AU - Stafa, Altin
AU - Garone, Caterina
AU - Franzoni, Emilio
AU - Abinun, Mario
AU - Mitchell, Patrick
AU - Mitra, Dipayan
AU - Friswell, Mark
AU - Nelson, John
AU - Shalev, Stavit A.
AU - Rice, Gillian I.
AU - Gornall, Hannah
AU - Szynkiewicz, Marcin
AU - Aymard, François
AU - Ganesan, Vijeya
AU - Prendiville, Julie
AU - Livingston, John H.
AU - Crow, Yanick J.
PY - 2010/8
Y1 - 2010/8
N2 - Aim: To describe a spectrum of intracerebral large artery disease in Aicardi-Goutières syndrome (AGS) associated with mutations in the AGS5 gene SAMHD1. Method: We used clinical and radiological description and molecular analysis. Results: Five individuals (three males, two females) were identified as having biallelic mutations in SAMHD1 and a cerebral arteriopathy in association with peripheral vessel involvement resulting in chilblains and ischaemic ulceration. The cerebral vasculopathy was primarily occlusive in three patients (with terminal carotid occlusion and basal collaterals reminiscent of moyamoya syndrome) and aneurysmal in two. Three of the five patients experienced intracerebral haemorrhage, which was fatal in two individuals. Post-mortem examination of one patient suggested that the arteriopathy was inflammatory in origin. Interpretation: Mutations in SAMHD1 are associated with a cerebral vasculopathy which is likely to have an inflammatory aetiology. A similar disease has not been observed in patients with mutations in AGS1 to AGS4, suggesting a particular role for SAMHD1 in vascular homeostasis. Our report raises important questions about the management of patients with mutations in SAMHD1.
AB - Aim: To describe a spectrum of intracerebral large artery disease in Aicardi-Goutières syndrome (AGS) associated with mutations in the AGS5 gene SAMHD1. Method: We used clinical and radiological description and molecular analysis. Results: Five individuals (three males, two females) were identified as having biallelic mutations in SAMHD1 and a cerebral arteriopathy in association with peripheral vessel involvement resulting in chilblains and ischaemic ulceration. The cerebral vasculopathy was primarily occlusive in three patients (with terminal carotid occlusion and basal collaterals reminiscent of moyamoya syndrome) and aneurysmal in two. Three of the five patients experienced intracerebral haemorrhage, which was fatal in two individuals. Post-mortem examination of one patient suggested that the arteriopathy was inflammatory in origin. Interpretation: Mutations in SAMHD1 are associated with a cerebral vasculopathy which is likely to have an inflammatory aetiology. A similar disease has not been observed in patients with mutations in AGS1 to AGS4, suggesting a particular role for SAMHD1 in vascular homeostasis. Our report raises important questions about the management of patients with mutations in SAMHD1.
UR - http://www.scopus.com/inward/record.url?scp=77955145461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955145461&partnerID=8YFLogxK
U2 - 10.1111/j.1469-8749.2010.03727.x
DO - 10.1111/j.1469-8749.2010.03727.x
M3 - Article
C2 - 20653736
AN - SCOPUS:77955145461
VL - 52
SP - 725
EP - 732
JO - Developmental Medicine and Child Neurology
JF - Developmental Medicine and Child Neurology
SN - 0012-1622
IS - 8
ER -