Intracerebroventricular endothelin-1 (ET-1) produces Ca2+-mediated antinociception in mice

R. Nikolov, J. Maslarova, I. Semkova, S. Moyanova

Research output: Contribution to journalArticlepeer-review

Abstract

Intracerebroventricular (i.c.v.) administration of endothelin-1 (ET-1) at doses of 0.313, 0.625, 1.25, 2.5 and 5 pmol/mouse produced a strong antinociceptive effect as evaluated by hotplate method in mice. The effect was dose-dependent and lasted for more than 120 min. The opioid receptor antagonist naloxone did not antagonize, and the cyclooxygenase inhibitors indomethacin and diclofenac slightly inhibited the ET-1 effect. The calcium overload blocker cinnarizine antagonized the antinociceptive effect of ET-1, suggesting that the ET-1 effect might be Ca2+-mediated.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume14
Issue number3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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