Intracerebroventricular endothelin-1 (ET-1) produces Ca2+-mediated antinociception in mice

R. Nikolov; J. Maslarova; I. Semkova; S. Moyanova

Intracerebroventricular endothelin-1 (ET-1) produces Ca2+-mediated antinociception in mice

R. Nikolov, J. Maslarova, I. Semkova, S. Moyanova

www.neuromed.it

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Abstract

Intracerebroventricular (i.c.v.) administration of endothelin-1 (ET-1) at doses of 0.313, 0.625, 1.25, 2.5 and 5 pmol/mouse produced a strong antinociceptive effect as evaluated by hotplate method in mice. The effect was dose-dependent and lasted for more than 120 min. The opioid receptor antagonist naloxone did not antagonize, and the cyclooxygenase inhibitors indomethacin and diclofenac slightly inhibited the ET-1 effect. The calcium overload blocker cinnarizine antagonized the antinociceptive effect of ET-1, suggesting that the ET-1 effect might be Ca²⁺-mediated.

Original language	English
Pages (from-to)	229-233
Number of pages	5
Journal	Methods and Findings in Experimental and Clinical Pharmacology
Volume	14
Issue number	3
Publication status	Published - 1992

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Intracerebroventricular endothelin-1 (ET-1) produces Ca2+-mediated antinociception in mice",

abstract = "Intracerebroventricular (i.c.v.) administration of endothelin-1 (ET-1) at doses of 0.313, 0.625, 1.25, 2.5 and 5 pmol/mouse produced a strong antinociceptive effect as evaluated by hotplate method in mice. The effect was dose-dependent and lasted for more than 120 min. The opioid receptor antagonist naloxone did not antagonize, and the cyclooxygenase inhibitors indomethacin and diclofenac slightly inhibited the ET-1 effect. The calcium overload blocker cinnarizine antagonized the antinociceptive effect of ET-1, suggesting that the ET-1 effect might be Ca2+-mediated.",

author = "R. Nikolov and J. Maslarova and I. Semkova and S. Moyanova",

year = "1992",

language = "English",

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AU - Nikolov, R.

AU - Maslarova, J.

AU - Semkova, I.

AU - Moyanova, S.

PY - 1992

Y1 - 1992

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AB - Intracerebroventricular (i.c.v.) administration of endothelin-1 (ET-1) at doses of 0.313, 0.625, 1.25, 2.5 and 5 pmol/mouse produced a strong antinociceptive effect as evaluated by hotplate method in mice. The effect was dose-dependent and lasted for more than 120 min. The opioid receptor antagonist naloxone did not antagonize, and the cyclooxygenase inhibitors indomethacin and diclofenac slightly inhibited the ET-1 effect. The calcium overload blocker cinnarizine antagonized the antinociceptive effect of ET-1, suggesting that the ET-1 effect might be Ca2+-mediated.

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JO - Methods and Findings in Experimental and Clinical Pharmacology

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Intracerebroventricular endothelin-1 (ET-1) produces Ca2+-mediated antinociception in mice

Abstract

ASJC Scopus subject areas

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