Intracerebroventricular injection of capsaicin or substance P provokes the micturition reflex in the rat

B. Dib, M. M. Corsi, A. Fulgenzi, M. E. Ferrero, M. Falchi

Research output: Contribution to journalArticlepeer-review

Abstract

Acute intracerebroventricular injection of 25 μg capsaicin or 40 μg substance P in isotonic saline elicited approximately similar effects on the micturition reflex, but capsaicin had twice as much effect as substance P. This effect is specific, since acute intracerebroventricular injection of isotonic saline did not produce the micturition reflex. It can be hypothesized that capsaicin and substance P may act on the brain micturition centers directly or by mediation of neuropeptides such as tachykinins, but other hypotheses are also made.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalInternational Journal of Tissue Reactions
Volume20
Issue number4
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Cell Biology
  • Physiology

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