Intracoronary angiotensin II potentiates coronary sympathetic vasoconstriction in humans

Antonio Saino, Guido Pomidossi, Rodolfo Perondi, Romano Valentini, Alberto Rimini, Lucia Di Francesco, Giuseppe Mancia

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: In humans with coronary artery disease, ACE inhibition attenuates coronary sympathetic vasoconstriction. Whether this is due to removal of angiotensin (Ang) II production or to a reduced bradykinin breakdown, however, is unknown. Methods and Results: In eight normotensive patients with angiographic evidence of mild left coronary artery lesions (≤50%), mean arterial pressure (MAP, intra-arterial catheter), heart rate (HR, ECG lead), coronary sinus blood flow (CBF, thermodilution method), and coronary vascular resistance (CVR, ratio between MAP and CBF) were measured before and during a 15-minute left intracoronary infusion of Ang II at a dose that had no direct coronary or systemic vasomotor effects. The same measurements were made before and during a 15-minute infusion of saline. A 2- minute cold pressor test (CPT) and a 45-second diving were performed at the end of either infusion period. These maneuvers were used because their coronary vasomotor effects are abolished by phentolamine and thus depend on sympathetic activation. During saline infusion, both CPT and diving caused a marked increase in MAP. HR increased with CPT and fell with diving. CBF increased in parallel to the MAP increase, with little change in CVR. The MAP and HR responses were similar during Ang II infusion, which, however, caused either no change or a reduction in CBF with a consequent marked increase in CVR with both CPT and diving. In four additional patients, the diameter of the stenotic vessels remained unchanged during the CPT performed under saline and Ang II infusion. Conclusions: Ang II markedly enhances sympathetic influences on coronary circulation in humans, presumably by acting at the arteriolar level. This may explain the blunting effect of ACE inhibition on sympathetic coronary vasoconstriction in patients with coronary artery disease.

Original languageEnglish
Pages (from-to)148-153
Number of pages6
JournalCirculation
Volume96
Issue number1
Publication statusPublished - Jul 1 1997

Fingerprint

Vasoconstriction
Diving
Angiotensin II
Coronary Artery Disease
Thermodilution
Coronary Circulation
Coronary Sinus
Phentolamine
Bradykinin
Vascular Resistance
Coronary Vessels
Arterial Pressure
Electrocardiography
Catheters
Heart Rate

Keywords

  • Angiotensin
  • Autonomic
  • Coronary disease
  • Nervous system
  • Reflex

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Saino, A., Pomidossi, G., Perondi, R., Valentini, R., Rimini, A., Di Francesco, L., & Mancia, G. (1997). Intracoronary angiotensin II potentiates coronary sympathetic vasoconstriction in humans. Circulation, 96(1), 148-153.

Intracoronary angiotensin II potentiates coronary sympathetic vasoconstriction in humans. / Saino, Antonio; Pomidossi, Guido; Perondi, Rodolfo; Valentini, Romano; Rimini, Alberto; Di Francesco, Lucia; Mancia, Giuseppe.

In: Circulation, Vol. 96, No. 1, 01.07.1997, p. 148-153.

Research output: Contribution to journalArticle

Saino, A, Pomidossi, G, Perondi, R, Valentini, R, Rimini, A, Di Francesco, L & Mancia, G 1997, 'Intracoronary angiotensin II potentiates coronary sympathetic vasoconstriction in humans', Circulation, vol. 96, no. 1, pp. 148-153.
Saino A, Pomidossi G, Perondi R, Valentini R, Rimini A, Di Francesco L et al. Intracoronary angiotensin II potentiates coronary sympathetic vasoconstriction in humans. Circulation. 1997 Jul 1;96(1):148-153.
Saino, Antonio ; Pomidossi, Guido ; Perondi, Rodolfo ; Valentini, Romano ; Rimini, Alberto ; Di Francesco, Lucia ; Mancia, Giuseppe. / Intracoronary angiotensin II potentiates coronary sympathetic vasoconstriction in humans. In: Circulation. 1997 ; Vol. 96, No. 1. pp. 148-153.
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