Intracoronary Brachytherapy, a Promising Treatment Option for Diabetic Patients: Results from a European Multicenter Registry (RENO)

Christoph K. Naber, Dietrich Baumgart, Raoul Bonan, Karl Wegscheider, Patrick W. Serruys, Antonio Colombo, Sigmund Silber, Eric Eeckhout, Holger Eggebrecht, Raumund Erbel, Philip Urban

Research output: Contribution to journalArticle

Abstract

Despite advances in the interventional treatment of coronary disease, diabetics still have double the case fatality rate as nondiabetics. The purpose of this analysis from the Radiation in Europe With Novoste (RENO) registry was to assess the clinical and angiographic 6-month outcome of diabetic patients in comparison to nondiabetic patients after localized β-radiation. A total of 1,098 patients (83.8% with in-stent restenosis) treated with the Novoste Beta-Cath system in Europe were enrolled in the RENO registry. Diabetes was, irrespective of the type of lesion treated, no significant risk factor for major adverse cardiac events or target vessel revascularization. Individuals with diabetes (n = 256) and without diabetes (n = 833) displayed no significant differences concerning clinical or angiographic endpoints. Vascular brachytherapy appears to be the first technique to even out the increased risk of diabetic patients undergoing percutaneous coronary interventions in the routine clinical setting. Thus, intracoronary brachytherapy represents a promising treatment option for diabetic patients.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalCatheterization and Cardiovascular Interventions
Volume61
Issue number2
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Brachytherapy
  • Diabetics
  • In-stent restenosis
  • Percutaneous transluminal coronary angioplasty

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Naber, C. K., Baumgart, D., Bonan, R., Wegscheider, K., Serruys, P. W., Colombo, A., Silber, S., Eeckhout, E., Eggebrecht, H., Erbel, R., & Urban, P. (2004). Intracoronary Brachytherapy, a Promising Treatment Option for Diabetic Patients: Results from a European Multicenter Registry (RENO). Catheterization and Cardiovascular Interventions, 61(2), 173-178. https://doi.org/10.1002/ccd.10795