Intracortical excitatory and inhibitory phenomena to paired transcranial magnetic stimulation in healthy human subjects: Differences between the right and left hemisphere

Paola Cicinelli, Raimondo Traversa, Massimiliano Oliveri, Maria Giuseppina Palmieri, Maria Maddalena Filippi, Patrizio Pasqualetti, Paolo Maria Rossini

Research output: Contribution to journalArticlepeer-review

Abstract

Intracortical inhibition (ICI) and facilitation (ICF) to paired magnetic stimuli reflect the activation of interneuronal circuits within the motor cortex. Intersubjects physiological variability of these phenomena, partly limits the usefulness of such method. Therefore, interhemispheric ICI/ICF differences might represent a more sensitive and less variable neurophysiological parameter to test the motor cortex excitability. Motor evoked potentials from the hand muscles were recorded in ten healthy subjects in a paired-pulse paradigm. Interstimulus intervals (ISIs) from 1 to 50 ms were used. The time course of ICI and ICF in the two hemispheres is consistent with minimal interhemispheric asymmetries. The interhemispheric differences of ICI and ICF could be a valuable neurophysiological marker for the diagnosis, prognosis and follow-up of neurological diseases characterized by monohemispheric damage and lateralized motor deficits. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalNeuroscience Letters
Volume288
Issue number3
DOIs
Publication statusPublished - Jul 21 2000

Keywords

  • Interhemispheric asymmetries
  • Intracortical excitability
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

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