TY - JOUR
T1 - Intracortical excitatory and inhibitory phenomena to paired transcranial magnetic stimulation in healthy human subjects
T2 - Differences between the right and left hemisphere
AU - Cicinelli, Paola
AU - Traversa, Raimondo
AU - Oliveri, Massimiliano
AU - Palmieri, Maria Giuseppina
AU - Filippi, Maria Maddalena
AU - Pasqualetti, Patrizio
AU - Rossini, Paolo Maria
PY - 2000/7/21
Y1 - 2000/7/21
N2 - Intracortical inhibition (ICI) and facilitation (ICF) to paired magnetic stimuli reflect the activation of interneuronal circuits within the motor cortex. Intersubjects physiological variability of these phenomena, partly limits the usefulness of such method. Therefore, interhemispheric ICI/ICF differences might represent a more sensitive and less variable neurophysiological parameter to test the motor cortex excitability. Motor evoked potentials from the hand muscles were recorded in ten healthy subjects in a paired-pulse paradigm. Interstimulus intervals (ISIs) from 1 to 50 ms were used. The time course of ICI and ICF in the two hemispheres is consistent with minimal interhemispheric asymmetries. The interhemispheric differences of ICI and ICF could be a valuable neurophysiological marker for the diagnosis, prognosis and follow-up of neurological diseases characterized by monohemispheric damage and lateralized motor deficits. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - Intracortical inhibition (ICI) and facilitation (ICF) to paired magnetic stimuli reflect the activation of interneuronal circuits within the motor cortex. Intersubjects physiological variability of these phenomena, partly limits the usefulness of such method. Therefore, interhemispheric ICI/ICF differences might represent a more sensitive and less variable neurophysiological parameter to test the motor cortex excitability. Motor evoked potentials from the hand muscles were recorded in ten healthy subjects in a paired-pulse paradigm. Interstimulus intervals (ISIs) from 1 to 50 ms were used. The time course of ICI and ICF in the two hemispheres is consistent with minimal interhemispheric asymmetries. The interhemispheric differences of ICI and ICF could be a valuable neurophysiological marker for the diagnosis, prognosis and follow-up of neurological diseases characterized by monohemispheric damage and lateralized motor deficits. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - Interhemispheric asymmetries
KW - Intracortical excitability
KW - Transcranial magnetic stimulation
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U2 - 10.1016/S0304-3940(00)01216-7
DO - 10.1016/S0304-3940(00)01216-7
M3 - Article
C2 - 10889335
AN - SCOPUS:0034698485
VL - 288
SP - 171
EP - 174
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -