Intracranial cavernoma and speckled lentiginous nevus: Extending the spectrum of phakomatoses?

Giorgio B. Boncoraglio, Eugenio A. Parati, Elisa Ciceri, Rosa Rinaldi, Giovanni L. Capella

Research output: Contribution to journalArticlepeer-review


Phakomatosis refers to several malformation syndromes with simultaneous involvement of the skin, the eye, and the central nervous system by developmental lesions. Speckled lentiginous nevus (SLN), a subtype of congenital melanocytic nevi, is usually an isolate, harmless finding. Here, we report the case of a 52-year-old woman with congenital left laterocervical SLN associated with an ipsilateral intracranial extra-axial cavernous angioma, a yet not described association to date. After revision of the literature, we suggest that both these lesions could be correlated in the setting of an atypical, yet unclassifiable form of phakomatosis, such as phakomatosis pigmentovascularis or SLN syndrome. We also propose that patients with bizarre, geometrical, pigmented or vascular cervicocranial skin lesions should undergo a thorough neurologic and ophthalmologic evaluation.

Original languageEnglish
Pages (from-to)841-844
Number of pages4
JournalNeurological Sciences
Issue number6
Publication statusPublished - Dec 2010


  • Intracranial cavernous angioma
  • Phakomatosis
  • Speckled lentiginous nevus

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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