Intracranial extension of orbital inflammatory pseudotumor: A case report and literature review

Enrico Tedeschi, Lorenzo Ugga, Ferdinando Caranci, Francesca Califano, Sirio Cocozza, Giacomo Lus, Arturo Brunetti

Research output: Contribution to journalArticlepeer-review


Background: Orbital inflammatory pseudotumor is a rare inflammatory condition of unknown cause that may extend intracranially, usually as a dural-based infiltrate. Here we report the first case of orbital pseudotumor presenting with intra-axial Magnetic Resonance Imaging (MRI) changes. Case presentation: A 57-year-old white female, with a 3-month history of headache and right palpebral edema, presented with marked right temporal lobe edema with ominous MRI appearance, and ipsilateral alterations of orbital and periorbital structures. Following steroid therapy, both intracranial and orbital involvement dramatically improved. Conclusion: Orbital inflammatory pseudotumor with chronic inflammation may infrequently present with intracranial involvement, mimicking more aggressive diseases, even showing intra-axial enhancement after i.v. contrast administration in brain MRI. Awareness of this possibility may help neurologists to choose the appropriate therapeutic approach.

Original languageEnglish
Article number29
JournalBMC Neurology
Issue number1
Publication statusPublished - Feb 29 2016


  • Intracranial extension
  • Magnetic resonance imaging
  • MRI
  • Orbital inflammatory pseudotumor
  • Orbital mass

ASJC Scopus subject areas

  • Clinical Neurology


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