Intracranial internal carotid artery changes in acromegaly: a quantitative magnetic resonance angiography study

Renzo Manara, Joseph Gabrieli, Valentina Citton, Filippo Ceccato, Silvia Rizzati, Giulia Bommarito, Chiara Briani, Alessandro Della Puppa, Francesca Dassie, Laura Milanese, Francesco Di Salle, Mario Ermani, Carla Scaroni, Chiara Martini, Pietro Maffei

Research output: Contribution to journalArticlepeer-review


Purpose: Although cerebrovascular mortality is increased up to eightfold in acromegaly, intracranial internal carotid artery (ICA) changes have not been well investigated. This is a magnetic resonance angiography (MRA) quantitative cross-sectional study of ICA tortuosity, ectasia and intercarotid distance in acromegalic patients with subsequent analysis of concomitant clinical, laboratory and neuroimaging findings. Methods: One hundred seventy six acromegalic patients (mean-age 55 ± 14 years, age range 21–88, 92 females) and 104 subjects with headache or transient neurological deficits underwent MRA with the same 1.5 T scanner. Clinical data, laboratory and pituitary adenoma imaging findings were recorded. Using a commercially available software, we measured the tortuosity index [(curved/linear ICA length from C3-midpoint to intracranial bifurcation) − 1], ICA ectasia index (intracavernous/petrous ICA diameter) and intercarotid distance at C3 and C4 levels. Results: Mean ICA tortuosity and ectasia indices were increased in acromegalic patients compared with controls (1.06 ± 0.29 vs 0.93 ± 0.26, p 

Original languageEnglish
Pages (from-to)414-422
Number of pages9
Issue number5
Publication statusPublished - Oct 1 2014


  • Acromegaly
  • Ectasia
  • ICA
  • MRA
  • Tortuosity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)


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