Intracranial pressure management in patients with traumatic brain injury: An update

Research output: Contribution to journalReview articlepeer-review


Purpose of review Intracranial pressure (ICP) monitoring and treatment is central in the management of traumatic brain injury. Despite 4 decades of clinical use, several aspects remain controversial, including the indications for ICP and treatment options. Recent findings Two major trials tested surgical decompression and mild hypothermia as treatments for high ICP. Both were rigorous, randomized, multicenter studies, with different designs. Decompression was tested for ICP refractory to conventional treatment, whereas hypothermia was offered as an alternative to conventional medical therapy. Decompression reduced mortality, but at the expense of more disability. The hypothermia trial was stopped because of a worse outcome in the treated arm. Indications for ICP monitoring have been reviewed and new international guidelines issued. New contributions published in 2016 have dealt with computerized analysis for predicting ICP crises; noninvasive or innovative methods for measuring ICP; reassessment of standard therapeutic interventions, such as hypertonic solutions and the level of intensity of ICP therapy. Summary Aggressive strategies for ICP control, like surgical decompression or hypothermia, carefully tested, have controversial effects on outcome. Several articles have made worthwhile contributions to important clinical issues, but with no real breakthroughs.

Original languageEnglish
Pages (from-to)110-114
Number of pages5
JournalCurrent Opinion in Critical Care
Issue number2
Publication statusPublished - Apr 1 2017


  • decompression
  • hypothermia
  • intracranial pressure
  • outcome
  • traumatic brain injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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