Intracranial tumors after radiation therapy: Role of 99mTc- tetrofosmin SPECT/CT with a hybrid camera

Luca Filippi, Riccardo Santoni, Pompeo Nicolì, Roberta Danieli, Orazio Schillaci

Research output: Contribution to journalArticlepeer-review


Background: We evaluated the value of single-photon emission computed tomography/computed tomography (SPECT/CT) with a hybrid camera for 99mTc-tetrofosmin (TF) imaging of brain tumors and metastases after radiotherapy. Methods: Forty (40) patients (27 with primary brain tumors and 13 with intracranial metastases) were examined 6 months after radiation therapy. SPECT images were first evaluated alone and then reinterpreted by adding the anatomic (CT) data. Tumor-to-background ratio values were calculated in the nonattenuation-corrected (T1/B1) and in the CT-attenuation-corrected (T2/B2) images. Scintigraphic results were compared with clinical follow-up. Results: SPECT was true positive for viable tumor tissue in 21 patients and negative in 19. SPECT/CT contributed in 10 of 40 patients (25%): It improved the visualization of lesions in the deep temporal lobe, in the orbital region, and in the posterior fossa. SPECT/CT was useful in 4 of 8 patients with suspicion of radionecrosis. The hybrid camera did not significantly contribute both in patients with a negative scan or with large frontotemporal tumors. When all the lesions were considered, no significant difference was found between T1/B1 and T2/B2. In small lesions (

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalCancer Biotherapy and Radiopharmaceuticals
Issue number2
Publication statusPublished - Apr 1 2009


  • Brain tumors
  • Hybrid camera
  • Tetrofosmin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology


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