Intracranial venous haemodynamics in multiple sclerosis

Paolo Zamboni, Erica Menegatti, Ilaria Bartolomei, Roberto Galeotti, Anna Maria Malagoni, Giovanna Tacconi, Fabrizio Salvi

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences in PDV, characterized by negative values (16.2±1 cm/sec in controls vs. -1.3 ±2.6 cm/sec in MS, respectively, p

Original languageEnglish
Pages (from-to)252-258
Number of pages7
JournalCurrent Neurovascular Research
Volume4
Issue number4
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Multiple Sclerosis
Hemodynamics
Cerebral Veins
Transverse Sinuses
Posture
Information Systems
Ultrasonography
Thorax
Color
Population

Keywords

  • Cerebral veins
  • Multiple sclerosis
  • Transcranial color-coded duplex sonography
  • Venous haemodynamics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Zamboni, P., Menegatti, E., Bartolomei, I., Galeotti, R., Malagoni, A. M., Tacconi, G., & Salvi, F. (2007). Intracranial venous haemodynamics in multiple sclerosis. Current Neurovascular Research, 4(4), 252-258. https://doi.org/10.2174/156720207782446298

Intracranial venous haemodynamics in multiple sclerosis. / Zamboni, Paolo; Menegatti, Erica; Bartolomei, Ilaria; Galeotti, Roberto; Malagoni, Anna Maria; Tacconi, Giovanna; Salvi, Fabrizio.

In: Current Neurovascular Research, Vol. 4, No. 4, 11.2007, p. 252-258.

Research output: Contribution to journalArticle

Zamboni, P, Menegatti, E, Bartolomei, I, Galeotti, R, Malagoni, AM, Tacconi, G & Salvi, F 2007, 'Intracranial venous haemodynamics in multiple sclerosis', Current Neurovascular Research, vol. 4, no. 4, pp. 252-258. https://doi.org/10.2174/156720207782446298
Zamboni P, Menegatti E, Bartolomei I, Galeotti R, Malagoni AM, Tacconi G et al. Intracranial venous haemodynamics in multiple sclerosis. Current Neurovascular Research. 2007 Nov;4(4):252-258. https://doi.org/10.2174/156720207782446298
Zamboni, Paolo ; Menegatti, Erica ; Bartolomei, Ilaria ; Galeotti, Roberto ; Malagoni, Anna Maria ; Tacconi, Giovanna ; Salvi, Fabrizio. / Intracranial venous haemodynamics in multiple sclerosis. In: Current Neurovascular Research. 2007 ; Vol. 4, No. 4. pp. 252-258.
@article{b456baa2634540f2a2f93f9b1054a4dc,
title = "Intracranial venous haemodynamics in multiple sclerosis",
abstract = "In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences in PDV, characterized by negative values (16.2±1 cm/sec in controls vs. -1.3 ±2.6 cm/sec in MS, respectively, p",
keywords = "Cerebral veins, Multiple sclerosis, Transcranial color-coded duplex sonography, Venous haemodynamics",
author = "Paolo Zamboni and Erica Menegatti and Ilaria Bartolomei and Roberto Galeotti and Malagoni, {Anna Maria} and Giovanna Tacconi and Fabrizio Salvi",
year = "2007",
month = "11",
doi = "10.2174/156720207782446298",
language = "English",
volume = "4",
pages = "252--258",
journal = "Current Neurovascular Research",
issn = "1567-2026",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - Intracranial venous haemodynamics in multiple sclerosis

AU - Zamboni, Paolo

AU - Menegatti, Erica

AU - Bartolomei, Ilaria

AU - Galeotti, Roberto

AU - Malagoni, Anna Maria

AU - Tacconi, Giovanna

AU - Salvi, Fabrizio

PY - 2007/11

Y1 - 2007/11

N2 - In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences in PDV, characterized by negative values (16.2±1 cm/sec in controls vs. -1.3 ±2.6 cm/sec in MS, respectively, p

AB - In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences in PDV, characterized by negative values (16.2±1 cm/sec in controls vs. -1.3 ±2.6 cm/sec in MS, respectively, p

KW - Cerebral veins

KW - Multiple sclerosis

KW - Transcranial color-coded duplex sonography

KW - Venous haemodynamics

UR - http://www.scopus.com/inward/record.url?scp=36448997799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36448997799&partnerID=8YFLogxK

U2 - 10.2174/156720207782446298

DO - 10.2174/156720207782446298

M3 - Article

C2 - 18045150

AN - SCOPUS:36448997799

VL - 4

SP - 252

EP - 258

JO - Current Neurovascular Research

JF - Current Neurovascular Research

SN - 1567-2026

IS - 4

ER -