Intractable diarrhea of infancy with congenital intestinal mucosa abnormalities: Outcome of four cases

M. Gambarara, A. Diamanti, F. Ferretti, B. Papadatou, D. Knafelz, A. Pietrobattista, M. Castro

Research output: Contribution to journalArticle

Abstract

Microvillous inclusion disease (MID) and epithelial dysplasia (ED) or tufting enteropathy are the most frequent causes of intractable diarrhea with persistent villous atrophy and indefinite dependence on total parenteral nutrition (PN) from early infancy. Since these are intractable diseases, they have been proposed to be elective indication for early bowel transplantation in order to avoid complications, such as PN-related liver disease, that would require a combined small bowel-liver transplant. We describe four cases of intractable diarrhea, two with MID and two with ED, seeking to discover whether these diseases are really elective, early indications for bowel transplant. Among our four patients, only one with ED underwent transplantation. The prognosis of small bowel transplant is still poor and worse than that of prolonged HPN. Further study is necessary to achieve a safe HPN program. Referral for transplant (small bowel only or combined with liver) should be considered when there is a venous access reduction and/or severe and irreversible liver disease.

Original languageEnglish
Pages (from-to)3052-3053
Number of pages2
JournalTransplantation Proceedings
Volume35
Issue number8
DOIs
Publication statusPublished - Dec 2003

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Fingerprint Dive into the research topics of 'Intractable diarrhea of infancy with congenital intestinal mucosa abnormalities: Outcome of four cases'. Together they form a unique fingerprint.

  • Cite this