Intractable epilepsy in Turner syndrome associated with bilateral perisylvian hypoplasia: One case report

Salvatore Striano, Pasquale Striano, Fabio Tortora, Andrea Elefante

Research output: Contribution to journalArticle

Abstract

Turner syndrome (TS) is the most frequent sex abnormality in females, generally associated with a 45,X0 karyotype. Although neurological complications are frequently part of the clinical picture, serious brain abnormalities are quite rare in TS. Epilepsy in TS is not frequent and so far only few cases have been reported, usually associated with cortical dysplasias. We report a Turner patient showing severe neurological impairment, refractory epilepsy and MRI finding of bilateral perisylvian hypoplasia. The possible dysgenetic role of X-chromosome on cortical morphogenesis is also discussed.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalClinical Neurology and Neurosurgery
Volume108
Issue number1
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Cerebral dysplasia
  • Epilepsy
  • MRI
  • Turner syndrome
  • X-chromosome

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Neurology

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