Intracystic epidermal growth factor level is predictive of breast-cancer risk in women with gross cystic disease of the breast

Francesco Boccardo, Cristina Marenghi, Gloria Ghione, Alessio Pepe, Stefano Parodi, Alessandra Rubagotti

Research output: Contribution to journalArticle

Abstract

Women affected by gross cystic disease of the breast have an increased risk of breast cancer. We report here the incidence of breast cancer by cyst type and intracystic epidermal growth factor (EGF) concentration. Our retrospective study included 504 women who had at least I cyst aspiration between 1985 and 1993. Cyst fluids were processed for electrolyte concentration (n = 378), EGF concentration (n = 347) or both (n = 337). Age-standardized incidence ratios (SIRs) were estimated using the population of the Genoa Cancer Registry. A multivariate Poisson regression model was used to estimate relative risks (RRs) when the study groups were compared directly. By June 1999, 19 invasive breast cancers had developed in the cohort of women. The age SIR of breast cancer calculated for the whole cohort was 3.32 (95% confidence interval 2.00-5.18). The ratio was not affected by age and was only moderately increased in women with a positive family history of breast cancer and type I cysts (i.e., those with a Na+/K+ ratio

Original languageEnglish
Pages (from-to)260-265
Number of pages6
JournalInternational Journal of Cancer
Volume95
Issue number4
DOIs
Publication statusPublished - Jul 20 2001

Keywords

  • Breast cancer risk
  • Cyst type
  • Epidermal growth factor
  • Gross cystic disease of the breast
  • Intracystic EGF concentration

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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