Intraductal aspiration: A promising new tissue-sampling technique for the diagnosis of suspected malignant biliary strictures

Gabriele Curcio, Mario Traina, Filippo Mocciaro, Rosa Liotta, Raffaella Gentile, Ilaria Tarantino, Luca Barresi, Antonino Granata, Fabio Tuzzolino, Bruno Gridelli

Research output: Contribution to journalArticle

Abstract

Background: Brushing is the most commonly used technique for biliary sampling at ERCP, despite its limited sensitivity. Objective: To evaluate intraductal aspiration (IDA) as a new combined endoscopic technique for cytodiagnosis, its cellular adequacy, diagnostic accuracy for cancer detection, feasibility, and safety. Design: Prospective, observational study. Setting: Single tertiary referral center. Main Outcome Measurements: IDA cellular adequacy, diagnostic accuracy for cancer detection, feasibility, and safety. Patients and Methods: From April 2009 to September 2010, 42 consecutive patients with suspected malignant biliary stricture underwent ERCP, with tissue sampling obtained with IDA. IDA included performance of standard brushing in all patients. After standard brushing, to perform IDA, we removed the brush from its catheter and used the tip of the catheter as a scraping device. The tip was scraped back and forth across the stricture at least 10 times. The catheter and a suction line were connected to a specimen trap to obtain intraductal aspiration of fluids and samplings. Results: Our cytopathologists found adequate cellular yield in 39 of the 42 IDA samples (92.8%) versus 15 of the 42 brushing samples (35.7%) (P

Original languageEnglish
Pages (from-to)798-804
Number of pages7
JournalGastrointestinal Endoscopy
Volume75
Issue number4
DOIs
Publication statusPublished - Apr 2012

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

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