Intraepithelial γ/δ-positive T lymphocytes and intestinal villous atrophy

Giampaola Pesce, Fernando Pesce, Nicolò Fiorino, Arrigo Barabino, Barbara Villaggio, Giorgio Walter Canonica, Marcello Bagnasco

Research output: Contribution to journalArticle

Abstract

We have evaluated the expression of different molecular forms of T cell antigen receptor (TcR) in duodenal biopsies of pediatric patients with different forms of villous atrophy: celiac disease, autoimmune enteropathy, intractable diarrhea of unknown origin, and severe cow milk intolerance. A panel of monoclonal antibodies recognizing α/β and γ/δ TcR (and γ/δ TcR subsets) was used for immunostaining. The results showed an increase of T cells with γ/δ-type TcR in celiac patients and also in patients with other forms of villous atrophy with respect to normal controls. Amongst the γ/δ TcR-positive cells, the subset expressing the molecular product of Vδ1 region was the most represented. The γ/δ TcR-positive T cells were mainly located within the epithelium: few of them were observed in the lamina propria. On the basis of these results, we hypothesize that the increased homing of γ/δ TcR-positive T lymphocytes in gut epithelium observed in celiac disease is, at least in part, related to villous atrophy per se.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume110
Issue number3
Publication statusPublished - Jul 1996

Fingerprint

T-Cell Antigen Receptor
Atrophy
T-Lymphocytes
Celiac Disease
Epithelium
Abdomen
Diarrhea
Milk
Mucous Membrane
Monoclonal Antibodies
Pediatrics
Biopsy

Keywords

  • α/β T cell antigen receptor
  • γ/δ T cell antigen receptor
  • Autoimmune enteropathy
  • Celiac disease
  • Intraepithelial lymphocytes
  • Villous atrophy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Pesce, G., Pesce, F., Fiorino, N., Barabino, A., Villaggio, B., Canonica, G. W., & Bagnasco, M. (1996). Intraepithelial γ/δ-positive T lymphocytes and intestinal villous atrophy. International Archives of Allergy and Immunology, 110(3), 233-237.

Intraepithelial γ/δ-positive T lymphocytes and intestinal villous atrophy. / Pesce, Giampaola; Pesce, Fernando; Fiorino, Nicolò; Barabino, Arrigo; Villaggio, Barbara; Canonica, Giorgio Walter; Bagnasco, Marcello.

In: International Archives of Allergy and Immunology, Vol. 110, No. 3, 07.1996, p. 233-237.

Research output: Contribution to journalArticle

Pesce, G, Pesce, F, Fiorino, N, Barabino, A, Villaggio, B, Canonica, GW & Bagnasco, M 1996, 'Intraepithelial γ/δ-positive T lymphocytes and intestinal villous atrophy', International Archives of Allergy and Immunology, vol. 110, no. 3, pp. 233-237.
Pesce, Giampaola ; Pesce, Fernando ; Fiorino, Nicolò ; Barabino, Arrigo ; Villaggio, Barbara ; Canonica, Giorgio Walter ; Bagnasco, Marcello. / Intraepithelial γ/δ-positive T lymphocytes and intestinal villous atrophy. In: International Archives of Allergy and Immunology. 1996 ; Vol. 110, No. 3. pp. 233-237.
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