Intrafamilial transmission of hepatitis C virus in Italy: A systematic review

Chiara De Waure, Consuelo Cefalo, Giacomina Chiaradia, Antonella Sferrazza, Luca Miele, Giovanni Gasbarrini, Walter Ricciardi, Antonio Grieco, Giuseppe La Torre

Research output: Contribution to journalArticlepeer-review


Background Hepatitis C virus (HCV) transmission is mainly due to parenteral exposure; however, in absence of such risk factor, there are reports of intrafamilial spread of HCV and observational studies suggest an increased risk for households of infected subjects. The aim of our study was to systematically review and meta-analyse studies about HCV prevalence among households of HCV patients in Italy. Methods PubMed and Embase were searched to identify Italian studies about HCV intrafamilial transmission. Keywords used were: 'HCV', 'Hepatitis C', 'intrafamilial', 'family' and 'Italy'. Selected studies were reviewed to assess the quality and meta-analysed using StatsDirect software. Results 25 studies were selected. The pooled overall prevalence was 9% (95% CI 7.1% to 11.1%). The highest pooled prevalence was found among sexual partners of index cases: 14.7% (95% CI 10.7% to 19.2%) globally and 9.9% (95% CI 3.6% to 18.8%) and 17.6% (95% CI 12.1% to 24%) in northern and central-southern regions, respectively. The meta-analysis of high-quality studies yielded the lowest HCV prevalence. Conclusion To be a HCV patient household is a risk factor for HCV and counselling for these households should be provided.

Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalJournal of Epidemiology and Community Health
Issue number10
Publication statusPublished - Oct 2010

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology


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