TY - JOUR
T1 - Intrafamilial transmission of hepatitis delta virus
T2 - Molecular evidence
AU - Niro, Grazia A.
AU - Casey, John L.
AU - Gravinese, Eleonora
AU - Garrubba, Maria
AU - Conoscitore, Pasquale
AU - Sagnelli, Evangelista
AU - Durazzo, Marilena
AU - Caporaso, Nicola
AU - Perri, Francesco
AU - Leandro, Gioacchino
AU - Facciorusso, Domenico
AU - Rizzetto, Mario
AU - Andriulli, Angelo
PY - 1999/4
Y1 - 1999/4
N2 - Background/Aims: Epidemiologic studies have suggested that transmission of hepatitis delta virus (HDV) occurs by intrafamilial routes in some populations in southern Italy, where HDV infection is endemic. To further evaluate intrafamilial transmission of HDV, we obtained the partial sequence of the viral genome from HDV-RNA positive members of families in which two or more immediate family members were positive for HDV-RNA. Methods: The region analyzed was the semi-conserved region from nucleotides 908 to 1265. Sequences obtained from family members were compared with those obtained from a control group of 20 unrelated patients. Results: The mean genetic divergence among HDV isolates was 2.8±1.7% within the 9 families analyzed, and 7.6±2.2% among the control group of unrelated individuals (p
AB - Background/Aims: Epidemiologic studies have suggested that transmission of hepatitis delta virus (HDV) occurs by intrafamilial routes in some populations in southern Italy, where HDV infection is endemic. To further evaluate intrafamilial transmission of HDV, we obtained the partial sequence of the viral genome from HDV-RNA positive members of families in which two or more immediate family members were positive for HDV-RNA. Methods: The region analyzed was the semi-conserved region from nucleotides 908 to 1265. Sequences obtained from family members were compared with those obtained from a control group of 20 unrelated patients. Results: The mean genetic divergence among HDV isolates was 2.8±1.7% within the 9 families analyzed, and 7.6±2.2% among the control group of unrelated individuals (p
KW - Delta virus
KW - HDV stability
KW - Intrafamilial transmission
KW - Phylogenetic analysis
KW - Sequence divergence
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U2 - 10.1016/S0168-8278(99)80185-8
DO - 10.1016/S0168-8278(99)80185-8
M3 - Article
C2 - 10207796
AN - SCOPUS:0033029409
VL - 30
SP - 564
EP - 569
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 4
ER -