Intrafamilial transmission of hepatitis delta virus: Molecular evidence

Grazia A. Niro, John L. Casey, Eleonora Gravinese, Maria Garrubba, Pasquale Conoscitore, Evangelista Sagnelli, Marilena Durazzo, Nicola Caporaso, Francesco Perri, Gioacchino Leandro, Domenico Facciorusso, Mario Rizzetto, Angelo Andriulli

Research output: Contribution to journalArticlepeer-review


Background/Aims: Epidemiologic studies have suggested that transmission of hepatitis delta virus (HDV) occurs by intrafamilial routes in some populations in southern Italy, where HDV infection is endemic. To further evaluate intrafamilial transmission of HDV, we obtained the partial sequence of the viral genome from HDV-RNA positive members of families in which two or more immediate family members were positive for HDV-RNA. Methods: The region analyzed was the semi-conserved region from nucleotides 908 to 1265. Sequences obtained from family members were compared with those obtained from a control group of 20 unrelated patients. Results: The mean genetic divergence among HDV isolates was 2.8±1.7% within the 9 families analyzed, and 7.6±2.2% among the control group of unrelated individuals (p

Original languageEnglish
Pages (from-to)564-569
Number of pages6
JournalJournal of Hepatology
Issue number4
Publication statusPublished - Apr 1999


  • Delta virus
  • HDV stability
  • Intrafamilial transmission
  • Phylogenetic analysis
  • Sequence divergence

ASJC Scopus subject areas

  • Gastroenterology


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