Intraforaminal O2-O3 versus periradicular steroidal infiltrations in lower back pain: Randomized controlled study

Matteo Bonetti, Alessandro Fontana, Biagio Cotticelli, Giorgio Dalla Volta, Massimiliano Guindani, Marco Leonardi

Research output: Contribution to journalArticle

Abstract

Background and purpose. Reports about steroids and oxygen-ozone therapy to treat lower back pain have been increasing. The purpose of our study was to compare the clinical outcomes in patients treated with infiltrations of O2-O3 gas or steroids at short-, medium-, and long-term follow-up. Methods: A total of 306 patients (166 with primarily disk disease, 140 with nondisk vertebral disease) with acute or chronic low back and sciatic nerve pain received a CT-guided intraforaminal infiltration of an O2-O3 gas mixture or an periradicular infiltration of steroids. Neurologists unaware of the type of treatment assessed the patients. Results: At 1-week follow-up, most patients had a complete remission of pain, regardless of the treatment. At 6-month follow-up, differences in favor of O2-O3 treatment were significant in patients with disk disease (P = .0021) but not in those without disk disease (P = .0992). Clinical outcomes were poor in 13 (15.1%) of 86 patients receiving O2-O3 infiltration and in 18 (22.5%) of 80 patients receiving steroid injection (P = .2226). Among patients without disk disease, six (8.6%) of 70 patients receiving O2-O3 infiltration but 21.4% of the patients receiving steroid injections had poor outcomes (P = .0332). Conclusion. Oxygen-ozone treatment was highly effective in relieving acute and chronic lower back pain and sciatica. The gas mixture can be administered as a first treatment to replace epidural steroids.

Original languageEnglish
Pages (from-to)55
Number of pages1
JournalRivista Italiana di Ossigeno-Ozonoterapia
Volume5
Issue number1
Publication statusPublished - Apr 2006

Fingerprint

Low Back Pain
Steroids
Gases
Ozone
Therapeutics
Oxygen
Sciatica
Injections
Neuralgia
Acute Disease
Sciatic Nerve
Chronic Disease
Pain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Ophthalmology

Cite this

Bonetti, M., Fontana, A., Cotticelli, B., Volta, G. D., Guindani, M., & Leonardi, M. (2006). Intraforaminal O2-O3 versus periradicular steroidal infiltrations in lower back pain: Randomized controlled study. Rivista Italiana di Ossigeno-Ozonoterapia, 5(1), 55.

Intraforaminal O2-O3 versus periradicular steroidal infiltrations in lower back pain : Randomized controlled study. / Bonetti, Matteo; Fontana, Alessandro; Cotticelli, Biagio; Volta, Giorgio Dalla; Guindani, Massimiliano; Leonardi, Marco.

In: Rivista Italiana di Ossigeno-Ozonoterapia, Vol. 5, No. 1, 04.2006, p. 55.

Research output: Contribution to journalArticle

Bonetti, M, Fontana, A, Cotticelli, B, Volta, GD, Guindani, M & Leonardi, M 2006, 'Intraforaminal O2-O3 versus periradicular steroidal infiltrations in lower back pain: Randomized controlled study', Rivista Italiana di Ossigeno-Ozonoterapia, vol. 5, no. 1, pp. 55.
Bonetti, Matteo ; Fontana, Alessandro ; Cotticelli, Biagio ; Volta, Giorgio Dalla ; Guindani, Massimiliano ; Leonardi, Marco. / Intraforaminal O2-O3 versus periradicular steroidal infiltrations in lower back pain : Randomized controlled study. In: Rivista Italiana di Ossigeno-Ozonoterapia. 2006 ; Vol. 5, No. 1. pp. 55.
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