Intrafusal effects of botulinum toxin in post-stroke upper limb spasticity

C. Trompetto, M. Bove, L. Avanzino, G. Francavilla, A. Berardelli, G. Abbruzzese

Research output: Contribution to journalArticle

Abstract

A previous study in subjects with focal dystonia suggested that the greater and longer-lasting effect induced by botulinum toxin type A (BoNT-A) on the tonic vibration reflex (TVR) than on the maximal M-wave (M-max) might be the physiological marker of the toxin's action at the level of intrafusal muscle fibres. With this approach, we investigated the possible effect of BoNT-A on fusimotor synapses in eight patients with post-stroke spasticity (four with no residual motor capacity before treatment and four with partially spared muscle strength and residual motor capacity). TVR and M-max were recorded from the wrist and finger flexor muscles before treatment and at 1, 4 and 7 months afterwards. The TVR reduction was greater than the M-max reduction and remained fairly constant over time only in the subjects with a residual motor capacity before the treatment. This pilot study suggests that some degree of strength and active movement is necessary for the action of BoNT-A on intrafusal fibres.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalEuropean Journal of Neurology
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 2008

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Type A Botulinum Toxins
Botulinum Toxins
Vibration
Upper Extremity
Reflex
Stroke
Dystonic Disorders
Muscles
Muscle Strength
Wrist
Synapses
Fingers
Therapeutics

Keywords

  • Botulinum toxin
  • Intrafusal fibres
  • Spasticity
  • Tonic vibration reflex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Intrafusal effects of botulinum toxin in post-stroke upper limb spasticity. / Trompetto, C.; Bove, M.; Avanzino, L.; Francavilla, G.; Berardelli, A.; Abbruzzese, G.

In: European Journal of Neurology, Vol. 15, No. 4, 04.2008, p. 367-370.

Research output: Contribution to journalArticle

Trompetto, C. ; Bove, M. ; Avanzino, L. ; Francavilla, G. ; Berardelli, A. ; Abbruzzese, G. / Intrafusal effects of botulinum toxin in post-stroke upper limb spasticity. In: European Journal of Neurology. 2008 ; Vol. 15, No. 4. pp. 367-370.
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